Results 41 to 50 of about 16,748 (250)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

The biological role of iodine and iodine deficiency as pathogenetic factor of thyroid pathology in pregnant women and its prevention

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
The article presents the most important information about the role of iodine in biological nature, its participation in different biological processes, formation of thyroid hormones and their effects on different organs and cells. Much attention is given
V.I. Kravchenko, B.K. Medvedev
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations

Angewandte Chemie, EarlyView.
Mechanochemistry is redefining metal catalysis by controlling catalyst formulation, speciation, and deployment. This Review shows how milling, LAG, RAM, and TSE enable rapid metal‐complex assembly, distinctive catalytic manifolds, and scalable synthesis beyond solution chemistry.
Sourav Behera, Francesco Basoccu, Andrea Porcheddu   +2 more
wiley   +2 more sources

Iodine status in late pregnancy and psychosocial determinants of iodized salt use in rural northern Viet Nam

Bulletin of the World Health Organization, 2011
OBJECTIVE: To establish iodine status among pregnant women in rural northern Viet Nam and explore psychosocial predictors of the use of iodized salt in their households.
Jane Fisher, Thach Tran, Beverley Biggs, Tuan Tran, Terry Dwyer, Gerard Casey, Dang Hai Tho, Basil Hetze   +7 more
doaj  

Problem of Iodine Sufficiency in Republic of Belarus: Results of Introduction of Strategy to Control Iodine Deficiency

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
The results of introduction of strategy to control iodine deficiency in Republic of Belarus allowed the International Council for Control of Iodine Deficiency Disorders and Iodine Global Network to enter Belarus into the list of countries that attained ...
Т.V. Моkhort, N.D. Коlomiets, S.V. Petrenko, Е.V. Fеdorenko, А.P. Shеpеlkevich, А.V. Sоlntseva   +5 more
doaj   +1 more source

Overview of Iodine Intake

Southeastern European Medical Journal, 2022
Iodine is an essential element for human health. Food is the primary source of iodine, but the iodine content of local foods depends on the iodine content of the soil.
Vanja Vasiljev, Alen Subotić, Mihaela Marinović Glavić, Denis Juraga, Lovorka Bilajac, Bojan Jelaković, Tomislav Rukavina   +6 more
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

Iodine Deficiency Disorders Continue to be a Problem in the Asia Pacific Region

Journal of the ASEAN Federation of Endocrine Societies, 2014
Iodine deficiency disorders (IDD) due to inadequate dietary iodine is one of the major non-communicable diseases yet to be eliminated from our world, particularly in the Asia Pacific region.
Creswell J. Eastman
doaj