Results 51 to 60 of about 14,903 (246)

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

open access: yesChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich   +11 more
wiley   +1 more source

Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR‐Spectroscopy

open access: yesAngewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Diazirines are three‐membered, nitrogen‐containing heterocycles that decompose under light or heat to generate carbenes. For the past two decades, they have served mainly as minimally invasive tags in photoaffinity labeling (PAL). More recently, their value as versatile carbene precursors has been recognized.
Dominik Schnalzer   +4 more
wiley   +2 more sources

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine-v.4.0 [PDF]

open access: yes, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I Baianu
core   +1 more source

Physico‐Nutritional Profiling and Assessment of Proteins as Well as Soluble and Insoluble Phenolic Acids in Gamma Irradiated Wheat Grains Through SWATH‐MS and HPLC Analysis and Their Functionality

open access: yesFood Science &Nutrition, Volume 14, Issue 4, April 2026.
Gamma irradiation (Dmin 650 Gy) proved effective in controlling insect pest infestations in stored wheat grains which otherwise undergo extensive losses during storage. SWATH‐MS based proteomics affirmed integrity of major storage proteins including prolamines and increased extractability of phenolics (soluble free & conjugated) was observed in ...
S. Saxena   +6 more
wiley   +1 more source

Analysis of the clinical factors affecting excellent response of Iodine-131 treatment for pulmonary metastases from differentiated thyroid cancer

open access: yesHeliyon, 2023
Background: Iodiene-131 (131I) treatment is the primary therapeutic approach for imaging 131I-avid pulmonary metastases. The response to radioiodine (RAI) treatment is an important prognostic factor in patients with pulmonary metastases from ...
Xin-Yu Wu   +5 more
doaj   +1 more source

Motor and Cognitive Outcome After Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson's Disease Harboring GBA1 Variant

open access: yesMovement Disorders Clinical Practice, Volume 13, Issue 4, Page 973-984, April 2026.
Abstract Background Deep brain stimulation (DBS) is effective for Parkinson's disease (PD); however, its efficacy varies with genetic background, such as the GBA1 variant—the causative gene of Gaucher disease—associated with increased PD risk and cognitive decline after subthalamic nucleus (STN)‐DBS.
Hikaru Kamo   +14 more
wiley   +1 more source

A systematic review of treating recurrent head and neck cancer: a reintroduction of brachytherapy with or without surgery. [PDF]

open access: yes, 2018
Purpose: To review brachytherapy use in recurrent head and neck carcinoma (RHNC) with focus on its efficacy and complication rates. Material and methods: A literature search of PubMed, Ovid, Google Scholar, and Scopus was conducted from 1990 to 2017 ...
Bar-Ad, Voichita   +10 more
core   +1 more source

Yields of Cyclotron Produced Medical Isotopes: A Comparison of Theoretical Potential and Experimental Results [PDF]

open access: yes, 1979
Experimentally obtained yields of most of the medical radioisotopes, produced with cyclotrons through different nuclear reactions at various bombarding energies in laboratories around the world, are presented.
Chaudhri, M Anwar
core   +1 more source

Dry and humid heat acclimation induces similar adaptations and cross‐acclimation benefits in trained male cyclists

open access: yesThe Journal of Physiology, Volume 604, Issue 7, Page 2757-2777, 1 April 2026.
Abstract figure legend Adaptive responses to hot‐dry and warm‐humid heat acclimation. Abstract This study compared adaptive responses and cross‐acclimation between dry and humid heat acclimation (HA). In a cross‐over design, trained males completed a heat stress test in hot‐dry (Dry‐HST: 42°C, 25% relative humidity [RH]) and warm‐humid (Humid‐HST: 33°C,
Peter McDonald   +5 more
wiley   +1 more source

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