Results 31 to 40 of about 157 (113)

A novel radioiodination reagent for protein radiopharmaceuticals with L- lysine as a plasma-stable metabolizable linkage to liberate m-iodohippuric acid after lysosomal proteolysis

A novel radioiodination reagent for protein radiopharmaceuticals with L- lysine as a plasma-stable metabolizable linkage to liberate m-iodohippuric acid after lysosomal proteolysis
Radiochemical design of polypeptides using metabolizable linkages would be attractive to enhance target-selective localization of radioactivity for diagnostic and therapeutic nuclear medicine. However, while use of ester bonds as the linkage allows selective release of the designed radiometabolite from covalently conjugated polypeptide after lysosomal ...
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Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1. [PDF]

Mol Pharmacol, 2016
Esteva-Font C, Jin BJ, Lee S, Phuan PW, Anderson MO, Verkman AS.   +5 more
europepmc   +1 more source

(99m)Tc(CO)3(NTA): a (99m)Tc renal tracer with pharmacokinetic properties comparable to those of (131)I-OIH in healthy volunteers. [PDF]

J Nucl Med, 2010
Taylor AT, Lipowska M, Marzilli LG.
europepmc   +1 more source

Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease. [PDF]

Clin J Am Soc Nephrol, 2011
Meijer E, Bakker SJ, van der Jagt EJ, Navis G, de Jong PE, Struck J, Gansevoort RT.   +6 more
europepmc   +1 more source

TSPO 18 kDa (PBR) Targeted Photosensitizers for Cancer Imaging (PET) and PDT. [PDF]

ACS Med Chem Lett, 2011
Chen Y, Sajjad M, Wang Y, Batt C, Nabi HA, Pandey RK.   +5 more
europepmc   +1 more source

99mTc(CO)3-nitrilotriacetic acid: a new renal radiopharmaceutical showing pharmacokinetic properties in rats comparable to those of 131I-OIH. [PDF]

J Nucl Med, 2009
Lipowska M, Marzilli LG, Taylor AT.
europepmc   +1 more source

Renal 131I-hippuran extraction in man: effects of dopamine. [PDF]

Br J Clin Pharmacol, 2002
Hutchings M, Hesse B, Grønvall J, Olsen NV.   +3 more
europepmc   +1 more source

Structure-Based Design and in Silico Screening of Virtual Combinatorial Library of Benzamides Inhibiting 2-trans Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Predicted Pharmacokinetic Profiles. [PDF]

Int J Mol Sci, 2019
Kouman KC, Keita M, Kre N'Guessan R, Owono Owono LC, Megnassan E, Frecer V, Miertus S.   +6 more
europepmc   +1 more source

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM). [PDF]

Bioorg Med Chem, 2008
Merkler DJ, Asser AS, Baumgart LE, Carballo N, Carpenter SE, Chew GH, Cosner CC, Dusi J, Galloway LC, Lowe AB, Lowe EW, King L, Kendig RD, Kline PC, Malka R, Merkler KA, McIntyre NR, Romero M, Wilcox BJ, Owen TC.   +19 more
europepmc   +1 more source

Copper and its complexes in medicine: a biochemical approach. [PDF]

Mol Biol Int, 2011
Iakovidis I, Delimaris I, Piperakis SM.
europepmc   +1 more source