Results 61 to 70 of about 5,706,473 (323)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Crater formation by single ions, cluster ions and ion “showers” [PDF]
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2012 Abstract The various craters formed by giant objects, macroscopic collisions and nanoscale impacts exhibit an intriguing resemblance in shapes. At the same time, the arc plasma built up in the presence of sufficiently high electric fields at close look causes very similar damage on the surfaces.
Flyura Djurabekova +6 more
openaire +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Tạp chí Khoa học Đại học Cần Thơ, 2010 Sử dụng thuốc trừ sâu để diệt tạp và kích thích tôm lột xác đã xuất hiện trong nghề nuôi tôm ở Đồng Bằng Sông Cửu Long dù không được khuyến cáo. Nghiên cứu được thực hiện nhằm xác định độ độc của thuốc trừ sâu decis chứa hoạt chất deltamethrin lên tôm ...
Nguyễn Thanh Phương +3 more
doaj
Ion/ion chemistry of high-mass multiply charged ions [PDF]
Mass Spectrometry Reviews, 1998 Electrospray ionization has enabled the establishment of a new area of ion chemistry research based on the study of the reactions of high-mass multiply charged ions with ions of opposite polarity. The multiple-charging phenomenon associated with electrospray makes possible the generation of multiply charged reactant ions that yield charged products as ...
S A, McLuckey, J L, Stephenson
openaire +3 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Toward a New Phenomenon: Super-Cerenkov Radiation
, 2004 In this letter a new coherent gamma emission mechanism, called Super-Cerenkov radiation, is introduced. The SCR is expected to take place when the charged particle is moving in a medium with a phase velocity satisfying the super-coherent condition.
Ion, D. B., Ion, M. L.
core
Entanglement of Trapped-Ion Qubits Separated by 230 Meters [PDF]
, 2023 V. Krutyanskiy +15 more
openalex +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source