Results 61 to 70 of about 8,535,977 (341)

Addition of H_2O and O_2 to Acetone and Dimethylsulfoxide Ligated Uranyl(V) Dioxocations [PDF]

, 2009
Gas-phase complexes of the formula [UO_2(lig)]^+ (lig = acetone (aco) or dimethylsulfoxide (dmso)) were generated by electrospray ionization (ESI) and studied by tandem ion-trap mass spectrometry to determine the general effect of ligand charge donation ...
Bryantsev, Vyacheslav S., de Jong, Wibe A., Diallo, Mamadou S., Goddard, William A., III, Groenewald, Gary S., Leavitt, Christopher M., Van Stipdonk, Michael J.   +6 more
core   +1 more source

Models of electrolyte solutions from molecular descriptions: The example of NaCl solutions

, 2009
We present a method to derive implicit solvent models of electrolyte solutions from all-atom descriptions; providing analytical expressions of the thermodynamic and structural properties of the ions consistent with the underlying explicit solvent ...
J. M. G. Barthel, J.-P. Hansen, Jean-François Dufrêche, John Jairo Molina, L. Blum, Marie Jardat, Mathieu Salanne, Olivier Bernard, Pierre Turq, V. M. M. Lobo   +9 more
core   +3 more sources

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Adeniran, I., Amuzu, A., Braund, P.S., Burton, P.R., Casas, J.-P., Day, I.N.M., Drenos, F., Eriksson, P., Folkersen, L., Gaunt, T.R., Hancox, J.C., Hingorani, A.D., Humphries, S.E., Kivimaki, M., Kumari, M., Lawlor, D.A., Macfarlane, P.W., Nelson, C.P., Samani, N.J., Shah, S., Talmud, P.J., Tobin, M.D., Tomaszewski, M., Whittaker, J., Zhang, H.   +24 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

EPIPACTIS × SCHMALHAUSENII K. RICHT. (ORCHIDACEAE), A NEWLY IDENTIFED TAXON IN ROMANIAN FLORA [PDF]

Journal of Plant Development, 2019
The authors reports the presence in the Romanian wild flora of the nothospecies Epipactis × schmalhausenii. This taxon of hybrid origin (Epipactis atrorubens × E. helleborine subsp. helleborine) was recently identified, together with the two genitors, on
Remus DULUGEAC, Mihai BOBOCEA, Culiţă SÎRBU, Adrian OPREA   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Ion Channels and Personalized Medicine in Gynecological Cancers

Pharmaceuticals, 2023
Targeted therapy against cancer plays a key role in delivering safer and more efficient treatments. In the last decades, ion channels have been studied for their participation in oncogenic processes because their aberrant expression and/or function have ...
Ana Ramírez, Ingrid Ogonaga-Borja, Brenda Acosta, Andrea Jazmín Chiliquinga, Jaime de la Garza, Patricio Gariglio, Rodolfo Ocádiz-Delgado, Cecilia Bañuelos, Javier Camacho   +8 more
doaj   +1 more source

How Multivalency controls Ionic Criticality

, 2005
To understand how multivalency influences the reduced critical temperatures, Tce (z), and densities, roce (z), of z : 1 ionic fluids, we study equisized hard-sphere models with z = 1-3.
C. W. Outhwaite, H. Weingärtner, I. Iosilevski, J.-M. Caillol, Jean-Noël Aqua, M. J. Sparnaay, Michael E. Fisher, S. Ichimaru, Shubho Banerjee   +8 more
core   +3 more sources