Results 91 to 100 of about 942,347 (195)

Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential

Frontiers in Pharmacology, 2019
Monoclonal antibodies (mAbs) represent a rapidly growing pharmaceutical class of protein drugs that becomes an important part of the precision therapy. mAbs are characterized by their high specificity and affinity for the target antigen, which is mostly ...
Aurélien Haustrate, Aline Hantute-Ghesquier, Natalia Prevarskaya, V’yacheslav Lehen’kyi, V’yacheslav Lehen’kyi   +4 more
doaj   +1 more source

In-Silico Investigation of Phyllanthus niruri Phytochemicals as Hepatic Fibrosis Modulators

Biology and Life Sciences Forum
The liver is a pioneer internal organ that orchestrates major metabolic, detoxification, and endocrine roles. Acute factors like hepatitis and drug allergy and chronic causes like metabolic dysfunction-associated fatty liver disease (MASLD) and ...
Chithra Raju, Kavitha Sankaranarayanan
doaj   +1 more source

The sodium-leak channel, NALCN, in health and disease

Frontiers in Cellular Neuroscience, 2014
Ion channels are crucial components of cellular excitability and are involved in many neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors (GPCRs)-activated NALCN channel that is predominantly expressed in neurons ...
Maud eCochet-Bissuel, Maud eCochet-Bissuel, Maud eCochet-Bissuel, Maud eCochet-Bissuel, Philippe eLory, Philippe eLory, Philippe eLory, Philippe eLory, Arnaud eMonteil, Arnaud eMonteil, Arnaud eMonteil, Arnaud eMonteil   +11 more
doaj   +1 more source

Stretch-activated ion channels

Kidney International, 1995
Mechanosensitive or stretch-activated (SA) channels respond to membrane stress by changes in open probability. These channels exist in auditory cells, stretch receptors, muscle spindles, vascular endothelium, and other neurosensory tissues where their physiological function seems readily apparent.
openaire   +2 more sources

The odyssey of the TR(i)P journey to the cellular membrane

Frontiers in Cell and Developmental Biology
Ion channels are integral membrane proteins mediating ion flow in response to changes in their environment. Among the different types of ion channels reported to date, the super-family of TRP channels stands out since its members have been linked to many
Bastián Rivera, Bastián Rivera, Octavio Orellana-Serradell, Octavio Orellana-Serradell, Evrim Servili, Evrim Servili, Evrim Servili, Rodrigo Santos, Rodrigo Santos, Sebastián Brauchi, Sebastián Brauchi, Oscar Cerda, Oscar Cerda   +12 more
doaj   +1 more source

A study of heavy-heavy nuclear reactions [PDF]

A simplified theory for heavy ion scattering shows good agreement with heavy ion absorption experiments.
Khandelwal, G. S.
core   +1 more source

Antibiotic Loaded Phytosomes as a Way to Develop Innovative Lipid Formulations of Polyene Macrolides

Pharmaceutics
Background: The threat of antibiotic resistance of fungal pathogens and the high toxicity of the most effective drugs, polyene macrolides, force us to look for new ways to develop innovative antifungal formulations.
Svetlana S. Efimova, Olga S. Ostroumova
doaj   +1 more source

Kinetics and functional consequences of BK channels activation by N-type Ca2+ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons

Frontiers in Cellular Neuroscience
The back-propagation of an action potential (AP) from the axon/soma to the dendrites plays a central role in dendritic integration. This process involves an intricate orchestration of various ion channels, but a comprehensive understanding of the ...
Laila Ananda Blömer, Laila Ananda Blömer, Elisabetta Giacalone, Elisabetta Giacalone, Fatima Abbas, Fatima Abbas, Luiza Filipis, Luiza Filipis, Domenico Tegolo, Michele Migliore, Marco Canepari, Marco Canepari, Marco Canepari   +12 more
doaj   +1 more source

Pathophysiology of homocysteine: insights into ion channel dysfunction. [PDF]

Pflugers Arch
Chmúrčiaková N, Stringer RN, Cmarko L, Filipova A, Lacinova L, Weiss N.   +5 more
europepmc   +1 more source

Can neuron modeling constrained by ultrafast imaging data extract the native function of ion channels?

Frontiers in Computational Neuroscience, 2023
Luiza Filipis, Luiza Filipis, Marco Canepari, Marco Canepari, Marco Canepari   +4 more
doaj   +1 more source