Results 91 to 100 of about 948,699 (249)

Ion channels and epilepsy [PDF]

QJM, 2006
In order for cells to retain their integrity to water and yet permeate charged ions, the phospholipid cell membrane contains transmembrane proteins that allow the passage of specific ions from the interior of the cell to outside, and vice versa. There is a huge diversity of these ion channels.
openaire   +3 more sources

Optimal positron-beam excited plasma wakefields in Hollow and Ion-Wake channels

, 2015
A positron-beam interacting with the plasma electrons drives radial suck-in, in contrast to an electron-beam driven blow-out in the over-dense regime, $n_b>n_0$.
Katsouleas, T. C., Sahai, Aakash A.
core  

Electrophysiological classification of CACNA1G gene variants associated with neurodevelopmental and neurological disorders

Frontiers in Pharmacology
This study highlights the complementarity of automated patch-clamp (APC) and manual patch-clamp (MPC) approaches to describe the electrophysiological properties of eighteen Cav3.1 calcium channel variants associated with various neurological conditions ...
Amaël Davakan, Amaël Davakan, Leos Cmarko, Leos Cmarko, Leos Cmarko, Leos Cmarko, Barbara Ribeiro Oliveira-Mendes, Barbara Ribeiro Oliveira-Mendes, Claire Bernat, Claire Bernat, Najlae Boulali, Najlae Boulali, Jérôme Montnach, Jérôme Montnach, Stephanie E. Vallee, Mary B. Dinulos, Lydie Burglen, Lydie Burglen, Vincent Cantagrel, Norbert Weiss, Sophie Nicole, Sophie Nicole, Arnaud Monteil, Arnaud Monteil, Michel De Waard, Michel De Waard, Philippe Lory, Philippe Lory   +27 more
doaj   +1 more source

Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer

Frontiers in Pharmacology, 2020
Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, angiogenesis, metastasis, and ...
Alexis Díaz-García, Alexis Díaz-García, Diego Varela, Diego Varela   +3 more
doaj   +1 more source

Cardiac Ion Channels [PDF]

Circulation: Arrhythmia and Electrophysiology, 2009
The analysis of the molecular basis of the inherited cardiac arrhythmias has been the driving force behind the identification of the ion channels that generate the action potential. The genes encoding all the major ion channels have cloned and sequenced. The studies have revealed greater complexity than heretofore imagined.
openaire   +3 more sources

The conduction pore of a cardiac potassium channel. [PDF]

, 1998
Ion channels form transmembrane water-filled pores that allow ions to cross membranes in a rapid and selective fashion. The amino acid residues that line these pores have been sought to reveal the mechanisms of ion conduction and selectivity. The pore (P)
Goldstein, SA, Tai, KK
core  

A Quantum-mechanical description of ion motion within the confining potentials of voltage gated ion channels

, 2012
Voltage gated channel proteins cooperate in the transmission of membrane potentials between nerve cells. With the recent progress in atomic-scaled biological chemistry it has now become established that these channel proteins provide highly correlated ...
Bernroider G., Bernroider G., Briegel H. J., Corry B., Gustav Bernroider, Johann Summhammer, Thomas J. W., Vahid Salari   +7 more
core   +2 more sources

Complementary DMOS-VMOS integrated circuit structure [PDF]

, 1978
A high speed CMOS formed on a single semiconductor substrate includes a DMOS having an asymmetric channel and a VMOS with a relatively short channel length.
Jhabvala, M. O.
core   +1 more source

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

Nature Communications, 2017
LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide ...
Yeranddy A. Alpizar, Brett Boonen, Alicia Sanchez, Carole Jung, Alejandro López-Requena, Robbe Naert, Brecht Steelant, Katrien Luyts, Cristina Plata, Vanessa De Vooght, Jeroen A. J. Vanoirbeek, Victor M. Meseguer, Thomas Voets, Julio L. Alvarez, Peter W. Hellings, Peter H. M. Hoet, Benoit Nemery, Miguel A. Valverde, Karel Talavera   +18 more
doaj   +1 more source

Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

eLife, 2019
The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek, Brett Boonen, Alejandro López-Requena, Ariel Talavera, Yeranddy A Alpizar, Debapriya Ghosh, Nele Van Ranst, Bernd Nilius, Thomas Voets, Karel Talavera   +9 more
doaj   +1 more source