Results 111 to 120 of about 1,025,431 (370)

Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer

Frontiers in Pharmacology, 2020
Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, angiogenesis, metastasis, and ...
Alexis Díaz-García, Alexis Díaz-García, Diego Varela, Diego Varela   +3 more
doaj   +1 more source

Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments

FEBS Open Bio, EarlyView.
Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau, Concepción Iñiguez, Sebastià Capó‐Bauçà, Jeroni Galmés   +3 more
wiley   +1 more source

Cardiac Ion Channels [PDF]

Circulation: Arrhythmia and Electrophysiology, 2009
The analysis of the molecular basis of the inherited cardiac arrhythmias has been the driving force behind the identification of the ion channels that generate the action potential. The genes encoding all the major ion channels have cloned and sequenced. The studies have revealed greater complexity than heretofore imagined.
openaire   +3 more sources

Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors

Pharmaceutics
Background/Objectives: Phosphodiesterase 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, activate the cyclic guanosine monophosphate pathway resulting in vascular smooth muscle relaxation.
Anna I. Malykhina, Svetlana S. Efimova, Olga S. Ostroumova   +2 more
doaj   +1 more source

TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides

Frontiers in Immunology, 2020
Urinary tract infections (UTI) affect a large proportion of the population, causing among other symptoms, more frequent and urgent micturition. Previous studies reported that the gram-negative bacterial wall component lipopolysaccharides (LPS) trigger ...
Yeranddy A. Alpizar, Yeranddy A. Alpizar, Pieter Uvin, Pieter Uvin, Robbe Naert, Robbe Naert, Jan Franken, Jan Franken, Silvia Pinto, Silvia Pinto, Alicia Sanchez, Alicia Sanchez, Thomas Gevaert, Wouter Everaerts, Wouter Everaerts, Thomas Voets, Thomas Voets, Dirk De Ridder, Karel Talavera, Karel Talavera   +19 more
doaj   +1 more source

Multiple Thresholds in a Model System of Noisy Ion Channels

, 2006
Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model.
D. Johnston, F. Rieke, F. Theunissen, J.-H. Lee, Manfred L. Ristig, Michael J. Barber   +5 more
core   +1 more source

Angstrom Scale Ionic Memristors' Engineering with van der Waals Materials- A Route to Highly Tunable Memory States [PDF]

ACS Appl. Mater. Interfaces 2024, XXXX, XXX, XXX-XXX
Memristors that mimic brain functions are crucial for energy-efficient neuromorphic devices. Ion channels that emulate biological synapses are still in the early stages of development, especially the tunability of memory states. Here, we demonstrate that cations such as K+, Na+, Ca2+, and Al3+ intercalated in the interlayer spaces of vermiculite ...
arxiv   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

eLife, 2020
Developmental and epileptic encephalopathies (DEE) are a heterogeneous group of disorders characterized by epilepsy with comorbid intellectual disability.
Evelien Van Hoeymissen, Katharina Held, Ana Cristina Nogueira Freitas, Annelies Janssens, Thomas Voets, Joris Vriens   +5 more
doaj   +1 more source

On stochastic differential equation models for ion channel noise in Hodgkin-Huxley neurons

, 2010
The random transitions of ion channels between conducting and non-conducting states generate a source of internal fluctuations in a neuron, known as channel noise.
Famulare, Michael, Goldwyn, Joshua H., Imennov, Nikita S., Shea-Brown, Eric   +3 more
core   +1 more source