Results 121 to 130 of about 1,025,431 (370)

Evaluation of the effect of metal stents on dose perturbation in the carbon beam irradiation field

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Propose Carbon ion therapy is indicated for cases in which stents have been inserted, such as bile ducts, but the effect of metal stents on carbon ion therapy is unclear. In this study, the dose perturbation of carbon ion therapy caused by metallic bile duct stents was evaluated by dosimetry. Materials and methods Five different types of metal
Yuya Miyasaka, Tetsuya Ishizawa, Yoshihito Nawa, Hikaru Souda, Shohei Kawashiro, Hongbo Chai, Miyu Ishizawa, Hiraku Sato, Takeo Iwai   +8 more
wiley   +1 more source

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

Nature Communications, 2017
LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide ...
Yeranddy A. Alpizar, Brett Boonen, Alicia Sanchez, Carole Jung, Alejandro López-Requena, Robbe Naert, Brecht Steelant, Katrien Luyts, Cristina Plata, Vanessa De Vooght, Jeroen A. J. Vanoirbeek, Victor M. Meseguer, Thomas Voets, Julio L. Alvarez, Peter W. Hellings, Peter H. M. Hoet, Benoit Nemery, Miguel A. Valverde, Karel Talavera   +18 more
doaj   +1 more source

Monte Carlo modeling of radiation dose from radiation therapy with superficial x‐rays

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Superficial x‐rays (50–100 kVp) are used for treating non‐melanoma skin cancer and intraoperative radiation therapy (IORT). At these energies, the photoelectric effect significantly increases absorbed dose to bone compared to soft tissue.
Reham Barghash, Tiffany W. Martin, Amber R. Prebble, Del Leary   +3 more
wiley   +1 more source

Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

eLife, 2019
The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek, Brett Boonen, Alejandro López-Requena, Ariel Talavera, Yeranddy A Alpizar, Debapriya Ghosh, Nele Van Ranst, Bernd Nilius, Thomas Voets, Karel Talavera   +9 more
doaj   +1 more source

A Python package for fast GPU‐based proton pencil beam dose calculation

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Open‐source GPU‐based Monte Carlo (MC) proton dose calculation algorithms provide high speed and unparalleled accuracy but can be complex to integrate with new applications and remain slower than GPU‐based pencil beam (PB) methods, which sacrifice some physical accuracy for sub‐second plan calculation.
Mahasweta Bhattacharya, Calin Reamy, Heng Li, Junghoon Lee, William T. Hrinivich   +4 more
wiley   +1 more source

Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential

Frontiers in Pharmacology, 2019
Monoclonal antibodies (mAbs) represent a rapidly growing pharmaceutical class of protein drugs that becomes an important part of the precision therapy. mAbs are characterized by their high specificity and affinity for the target antigen, which is mostly ...
Aurélien Haustrate, Aline Hantute-Ghesquier, Natalia Prevarskaya, V’yacheslav Lehen’kyi, V’yacheslav Lehen’kyi   +4 more
doaj   +1 more source

Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]

, 1988
We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core  

Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors. It is important to achieve precise and accurate dose delivery and to establish reliable detector systems, particularly for clinical trials needed to help the clinical transfer of FLASH‐
Patrik Gonçalves Jorge, Reiner Geyer, Rémy Kinj, Luis Schiappacasse, Wendy Jeanneret‐Sozzi, Jean Bourhis, Fernanda Herrera, François Bochud, Claude Bailat, Raphaël Moeckli   +9 more
wiley   +1 more source

U-shaped bilayer graphene channel transistor with very high Ion/Ioff ratio

, 2011
A novel graphene transistor architecture is reported. The transistor has a U-shaped geometry and was fabricated using a gallium focused ion beam (FIB). The channel conductance was tuned with a back gate.
Boden, Stuart, Ghiass, Mohammad Adel, Mizuta, Hiroshi, Moktadir, Zakaria, Rutt, Harvey   +4 more
core   +1 more source

Accounting for TLD response to CBCT protocols in external beam radiotherapy dose monitoring

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose LiF thermoluminescent dosimeters (TLDs) are commonly used in radiation therapy to verify the delivered dose. Examples include dose verification for complicated treatment setups or cardiovascular implantable electronic devices (CIEDs). TLDs may be present for both the pre‐treatment imaging kilovoltage (kV) beam and the megavoltage (MV ...
Andrew J. White, Cliff G. Hammer, Matthew W. Brenner, Larry A. DeWerd, Kurt E. Stump, Wesley S. Culberson   +5 more
wiley   +1 more source