Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations
eLife, 2019 The devastating inherited disease cystic fibrosis (CF) is caused by mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel.
László Csanády, Beáta Töröcsik
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TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
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Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
Particle and Fibre Toxicology, 2017 Background Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents.
Alicia Sanchez +9 more
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Membranes, 2022 This study was focused on the action of lantibiotic nisin on the phospholipid membranes. Nisin did not produce ion-permeable pores in the membranes composed of DOPC or DOPE. The introduction of DOPS into bilayer lipid composition led to a decrease in the
Dayana N. Chernyshova +3 more
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Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]
, 1988 We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel [PDF]
, 2013 The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp. (NaVMs) has provided the basis for a molecular dynamics study defining the channel’s full ion translocation pathway and conductance ...
Bagneris, Claire +7 more
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Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]
, 2013 Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai +44 more
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Ion channel expression in human melanoma samples. in silico identification and experimental validation of molecular targets [PDF]
, 2019 Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (p 0.90 and p 90% in most cases).
D’Arcangelo, Daniela +5 more
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Mitochondrial Ion Channels [PDF]
Annual Review of Physiology, 2007 In work spanning more than a century, mitochondria have been recognized for their multifunctional roles in metabolism, energy transduction, ion transport, inheritance, signaling, and cell death. Foremost among these tasks is the continuous production of ATP through oxidative phosphorylation, which requires a large electrochemical driving force for ...
openaire +2 more sources
Stochastic dynamics of remote knock-on permeation in biological ion channels [PDF]
, 2013 Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF).
Eisenberg, Robert S. +5 more
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