Results 81 to 90 of about 1,025,431 (370)

Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family [PDF]

, 2013
We use Brownian dynamics (BD) simulations to study the ionic conduction and valence selectivity of a generic electrostatic model of a biological ion channel as functions of the fixed charge Qf at its selectivity filter.
Eisenberg, Robert S., Kaufman, Igor, Luchinsky, Dmitrii G., McClintock, Peter V. E., Tindjong, Rodrigue   +4 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Full Modeling of Field-Assisted Ion Exchange for Graded Index Buried Channel Optical Waveguides [PDF]

, 1990
The numerical modeling of field-assisted ion exchange in glass through a finite aperture is carried out. The effects of unequal ion mobilities and thermal diffusion are included we believe for the first time in the 2-D case.
Albert, Jacques, Lit, John W.Y.
core   +2 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Therapeutic Peptides to Treat Myocardial Ischemia-Reperfusion Injury

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases (CVD) including acute myocardial infarction (AMI) rank first in worldwide mortality and according to the World Health Organization (WHO), they will stay at this rank until 2030.
Carlota Fernandez Rico, Carlota Fernandez Rico, Karidia Konate, Emilie Josse, Joël Nargeot, Joël Nargeot, Stéphanie Barrère-Lemaire, Stéphanie Barrère-Lemaire, Prisca Boisguérin   +8 more
doaj   +1 more source

Monitoring Ion Channel Function In Real Time Through Quantum Decoherence

, 2009
In drug discovery research there is a clear and urgent need for non-invasive detection of cell membrane ion channel operation with wide-field capability.
Arhem, B. Stadler, Baaken, Balasubramanian, Balasubramanian, Bannai, Bradac, C. D. Hill, Cole, F. Caruso, Faklaris, Forn  s, Hall, Ide, J. H. Cole, J. Wrachtrup, Jelezko, Kramer, L. C. L. Hollenberg, L. T. Hall, Lundstrom, Maze, Mueller, Neugart, P. Mulvaney, Rabeau, Reimhult, Steinert, Tikhonov, Yamazaki, Yu   +30 more
core   +2 more sources

Trans-Bilayer Ion Conduction by Proline Containing Cyclic Hexapeptides and Effects of Amino Acid Substitutions on Ion Conducting Properties [PDF]

, 2010
Several ion channel forming cyclic peptides have been reported over the past two decades and various ion conducting mechanisms have been proposed. In this article, we report on amino acid substitutions in cyclic hexapeptides and their effects on the ion ...
Aoyagi, Haruhiko, Hayashi, Ryo, Jelokhani-Niaraki, Masoud, Kodama, Hiroaki, Osada, Saoshi, Taira, Junichi, Ueda, Toshihisa   +6 more
core   +2 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source