Results 81 to 90 of about 942,347 (195)
ChannelsKv10.1 is a voltage-gated K+ channel whose structure–function relationships remain incompletely understood, and whose ectopic expression is linked to tumorigenesis.
Froylán Gómez-Lagunas +1 more
doaj +1 more source
, 2012 Voltage gated channel proteins cooperate in the transmission of membrane potentials between nerve cells. With the recent progress in atomic-scaled biological chemistry it has now become established that these channel proteins provide highly correlated ...
Bernroider G. +7 more
core +2 more sources
Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors
PharmaceuticsBackground/Objectives: Phosphodiesterase 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, activate the cyclic guanosine monophosphate pathway resulting in vascular smooth muscle relaxation.
Anna I. Malykhina +2 more
doaj +1 more source
Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol
eLife, 2019 The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek +9 more
doaj +1 more source
Beam loading in the nonlinear regime of plasma-based acceleration
, 2008 A theory that describes how to load negative charge into a nonlinear, three-dimensional plasma wakefield is presented. In this regime, a laser or an electron beam blows out the plasma electrons and creates a nearly spherical ion channel, which is ...
C. Huang +11 more
core +1 more source
Complementary DMOS-VMOS integrated circuit structure [PDF]
, 1978 A high speed CMOS formed on a single semiconductor substrate includes a DMOS having an asymmetric channel and a VMOS with a relatively short channel length.
Jhabvala, M. O.
core +1 more source
Multiple solutions of steady-state Poisson-Nernst-Planck equations with steric effects
, 2014 Experiments measuring currents through single protein channels show unstable currents. Channels switch between 'open' or 'closed' states in a spontaneous stochastic process called gating.
Eisenberg, Bob, Lin, Tai-Chia
core +1 more source
Nature Communications, 2017 LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide ...
Yeranddy A. Alpizar +18 more
doaj +1 more source
Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions
eLife, 2017 CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, is opened by ATP binding to two cytosolic nucleotide binding domains (NBDs), but pore-domain mutations may also impair gating.
Ben Sorum +2 more
doaj +1 more source