Results 211 to 220 of about 3,160,213 (280)

DNA concentration in harvest affects retrovirus clearance capabilities of protein A chromatography

Biotechnology Progress, EarlyView.
Abstract Protein A chromatography is a key unit operation in biopharmaceutical purification, widely used to capture monoclonal antibodies (mAbs) from harvest cell culture fluid (HCCF). In addition to its primary function, protein A chromatography is also frequently tested for its ability to remove viruses. Although protein A specifically binds mAbs and
Lukas Döring, Sven Schubert, Nora Roos, Johannes Winderl, Annika Müller, Anna Ratermann, Matthias W. Kron, Jürgen Hubbuch   +7 more
wiley   +1 more source

Adsorption of Ethylenediaminetetraacetic Acid on a Gel-Type Ion-Exchange Resin for Purification of Liquid Waste Containing Cs Ions. [PDF]

Polymers (Basel), 2019
Kim J, Park CW, Lee KW, Lee TS.
europepmc   +1 more source

Development and application of a mechanistic model for protein A resolution of a bispecific antibody for process characterization and optimization

Biotechnology Progress, EarlyView.
Abstract Regeneron's bispecific technology, based on a fully human IgG antibody construct, consists of two distinct heavy chains and a common light chain co‐expressed in a single cell. The co‐expression of the two distinct heavy chains, one of which contains a dipeptide substitution that ablates Protein A binding, leads to the formation of three ...
Samantha Wadsworth, James Reilly, John Mattila, Christopher Cowan, Hanne Bak   +4 more
wiley   +1 more source

Flocculation using selected cationic polymers reduces high‐risk host cell proteins in monoclonal antibody processes already during primary recovery

Biotechnology Progress, EarlyView.
Flocculation using cationic polymers leads to the creation of large floc complexes. Negative charged species like cells, cell debris, and negatively charged host cell impurities like host cell DNA and host cell proteins are trapped within the complex while the positively charged monoclonal antibody stays in solution.
Anna‐Carina Frank, Daniel Komuczki, Gregor Stitz, Timon Kalchmayr, Clemens Grünwald‐Gruber, Clara Hofmann, Natalie Deiringer, Christine Rösch, Peter Satzer, Rainer Hahn   +9 more
wiley   +1 more source

Cyclic fractionation process for Saccharina latissima using aqueous chelator and ion exchange resin. [PDF]

J Appl Phycol, 2017
Sterner M, Ribeiro MS, Gröndahl F, Edlund U.   +3 more
europepmc   +1 more source

Graphene Materials for Sustainable Energy Applications: A Contemporary Perspective

Carbon Energy, EarlyView.
ABSTRACT Graphene has garnered significant attention as a promising material with great potential for contributing to sustainable energy initiatives, such as RE100 (100% renewable energy initiative) and CF100 (100% carbon‐free initiative). This review aims to explore the potential of graphene for advancing renewable energy applications by highlighting
Niraj Kumar, Seul‐Yi Lee, Roop L. Mahajan, Soo‐Jin Park   +3 more
wiley   +1 more source

Boosting Sodium Storage Activity and Kinetics of Hard Carbon by Remodeling Oxygen Chemistry

Carbon Energy, EarlyView.
A surface oxygen remodeling strategy is proposed to finely furnish the pseudographitic structure of hard carbon with rich closed pores and expanded interlayer spacings. Accordingly, the sodiation reactivity and kinetics are greatly reinforced to afford an elevated capacity of 360 mAh g−1 and outstanding rate capability of 225 mAh g−1 at 2 A g−1 ...
Xingling Hu, Weijia He, Jian‐Gan Wang, Hao Xu, Xin Li, Delin Xia, Junhui Dong, Jianfang Wang, Na Huang, Yang Zhang, Yanlin Li, Ding Nan, Chunguang Wei   +12 more
wiley   +1 more source

Recent Progress of Biomass‐Derived Nitrogen‐Doped Carbon Materials as Electrocatalysts: Carbonization, Functionalization, and Applications

Carbon Energy, EarlyView.
Integrating renewable energy with electrochemical conversion and storage is crucial for sustainable energy solutions. Nitrogen‐doped biomass‐derived carbon materials have emerged as effective catalysts for key reactions such as ORR, HER, and CO2RR. This review explores their synthesis, functionalization, characterization, and catalytic applications ...
Shilong Fu, Haiping Yang, Wiebren de Jong, Ruud Kortlever   +3 more
wiley   +1 more source

Durable Fuel Cell Cathode Enabled by Pt Embedded Nanoscale Carbon Network via a Scalable Process

Carbon Energy, EarlyView.
Platinum nanoparticles embedded nanoscale carbon network (Pt‐e‐Cn) are developed via a scalable flame spray pyrolysis process. Proton exchange membrane fuel cells (PEMFC) employing mesoporous Pt‐e‐Cn cathode electrocatalysts exhibit exceptional durability without compromising performance.
Suriya Venkatesan, Jens Mitzel, Tobias Morawietz, Emmanuelle Boehm‐Courjault, Deven P. Estes, Laure Guétaz, Indro Biswas, Jan Van Herle, Karsten Wegner, Pawel Gazdzicki, Kaspar Andreas Friedrich   +10 more
wiley   +1 more source

Electrospun Porous Materials for the Next‐Generation Proton Exchange Membrane Fuel Cells: Progress, Challenges, and AI‐Optimized Perspectives

Carbon Energy, EarlyView.
Incorporating AI to optimize solution, process, and environment enables efficient prediction of structural properties and performance, allowing tailoring of GDL, CL, and PEM fabrication to guide PEMFC toward 9.0 kW L‒1 by 2040. ABSTRACT The performance and commercial viability of proton exchange membrane fuel cells (PEMFCs) are constrained by key ...
Shangfeng Jiang, Panfeng Wang, You Gong, Zeyu Sun, Huatan Chen, Geng Wang, Ting Tao, Chuang Zhai, Xi Wang, Ruixin Chen, Jiaxin Jiang, Bingrong Zhang   +11 more
wiley   +1 more source