Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
Effect of the Resorcinol/Formaldehyde Ratio and the Temperature of the Resorcinol-Formaldehyde Gel Solidification on the Chemical Stability and Sorption Characteristics of Ion-Exchange Resins. [PDF]
Gels, 2021 Tokar E +4 more
europepmc +1 more source
Advanced Science, EarlyView.A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li +14 more
wiley +1 more source
, 2001 The extraction of caesium by resorcinol based resins was investigated. At high hydroxide concentration ([OH-] = 0.15 M), the alkali-metal cations' sorption selectivity (determined in competitive extraction system) for resorcinol resins was found to be Cs+
Lemaire, M +3 more
core +1 more source
Analysis of technological and ecological aspects of removing boron from natural water
Тонкие химические технологии, 2011 The review covers some aspects of boron chemistry, its influence on the human organism, methods of boron disposal from water, and prospects of technologies for boron removal from water in the Russian Federation.
G. A. Samburskiy
doaj
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor
Advanced Science, EarlyView.The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao +11 more
wiley +1 more source
[Determination of eight organic residues in ion exchange resins by headspace gas chromatography]. [PDF]
Se Pu, 2021 Zhu H, Zang Y, Zhang G, Lu L, Xia H.
europepmc +1 more source
Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction
Advanced Science, EarlyView.This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng +12 more
wiley +1 more source
Synthesis and characterisation of aurothiosulfate-selective magnetic ion exchange resins
, 2010 A series of novel ion-exchange resins was prepared based upon the commercial Magnetic Ion Exchange (MIEXTm) substrate produced by Orica Watercare for the selective adsorption and removal of aurothiosulfate from ammoniacal thiosulfate leach liquors.
Marshall, Elijah Michael (15927785)
core +1 more source
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, EarlyView.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source