Results 111 to 120 of about 7,700,334 (333)

Evolution of kinklike fluctuations associated with ion pickup within reconnection outflows in the Earth's magnetotail

, 2009
Magnetic reconnection (MR) in Earth's magnetotail is usually followed by a systemwide redistribution of explosively released kinetic and thermal energy.
A. Runov, Erkaev N., Grinsted A., Laitinen T., M. P. Leubner, Runov A., Sergeev V., Sergeev V., V. Angelopoulos, W. Baumjohann, Z. Vörös, Zhang T.   +11 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

A Quantum Repeater Node with Trapped Ions: A Realistic Case Example

, 2016
We evaluate the feasibility of the implementation of two quantum repeater protocols with an existing experimental platform based on a $^{40}$Ca$^+$-ion in a segmented micro trap, and a third one that requires small changes to the platform. A fiber cavity
Hettrich, Max, Pfister, Andreas Daniel, Poschinger, Ulrich Georg, Salz, Marcel, Schmidt-Kaler, Ferdinand   +4 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Tris(pentafluorophenyl)borane-Catalyzed Carbenium Ion Generation and Autocatalytic Pyrazole Synthesis-A Computational and Experimental Study. [PDF]

Angew Chem Int Ed Engl, 2021
Dasgupta A, Babaahmadi R, Pahar S, Stefkova K, Gierlichs L, Yates BF, Ariafard A, Melen RL.   +7 more
europepmc   +1 more source

Berry Phase Generation and Measurement in a Single Trapped Ion

, 2012
In this work, we propose a new design of an ion trap which can enable us to generate state specific Berry phase in a single trapped ion. Such a design will enable us to study the physics at the boundary of abelian and non-abelian symmetries and can also ...
Avron, B. Dutta Roy, Berry, D. De Munshi, Diddams, Duan, Fortson, Horsley, Huang, Huntemann, Itano, Leanhardt, M. Mukherjee, Mandal, Margolis, Meyer, Monroe, Roos, Tycko, Vutha, Wang, Webb, Wilczek   +22 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Characteristics of negative ion generation in large area negative ion source based on cavity ring-down spectroscopy

He jishu
BackgroundThe neutral beam injection system (NBI) has the highest heating efficiency and the clearest physical mechanism, so it has become one of the main auxiliary heating methods used in the world's large magnetic confinement controlled thermonuclear ...
ZHU Tengsai, LIANG Lizhen, XIE Yahong, CAO Zhengkun, PENG Xufeng, HU Chundong   +5 more
doaj   +1 more source