Results 81 to 90 of about 4,111,539 (306)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Research on Negative Helium Ion Beam Generation Technology
Yuanzineng kexue jishuTandem accelerator can generate MeV-level positive ion beam, of which He ion beam can be used for experimental research and industrial applications such as ion beam analysis and ion implantation, which is an indispensable ion beam for tandem accelerator.
CHEN Haonan1, 2, CUI Baoqun1, 2, TANG Bing1, 2, CHEN Lihua1, 2, MA Ruigang1, 2, MA Yingjun1, 2, MA Xie1, 2, ZHANG Yifan1, 2, ZHAO Jiange1, 2, WANG Yunfeng1, 2, YANG Chao1, 2, YU Rongkai1, 2
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Bamboo beheading knives [picture]
, 1933 Part of collection: Ion Idriess glass plate negative collection.; Title from caption in: Drums of Mer.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3282627; Published in: Drums of Mer / by Ion I.
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Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
A type of the northern Australian "mounteds" [picture]
, 1935 Part of collection: Ion Idriess glass plate negative collection.; Title from caption in: Man tracks.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3298452; Published in: Man tracks : with the mounted police in ...
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Nature CommunicationsMoisture-induced ion diffusion in nanostructured materials is a promising route for high-performance power generation, yet achieving the continuous ion migration necessary for long-term operation remains challenging.
Xulei Lu +9 more
doaj +1 more source