Results 41 to 50 of about 389,730 (280)

DataSheet_1_Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment.pdf

open access: yes, 2021
We have previously reported that metastases from all malignancies are characterized by a core program of gene expression that suppresses extracellular matrix interactions, induces vascularization/tissue remodeling, activates the oxidative metabolism, and
Gulimirerouzi Fnu (11855849)   +1 more
core   +1 more source

Overdominant expression of related genes of ion homeostasis improves K+ content advantage in hybrid tobacco leaves

open access: yesBMC Plant Biology, 2022
Background Potassium(K+) plays a vital role in improving the quality of tobacco leaves. However, how to improve the potassium content of tobacco leaves has always been a difficult problem in tobacco planting. K+ content in tobacco hybrid is characterized
Kai Pi   +8 more
doaj   +1 more source

Regulation of lysosomal ion homeostasis by channels and transporters [PDF]

open access: yesScience China Life Sciences, 2016
Lysosomes are the major organelles that carry out degradation functions. They integrate and digest materials compartmentalized by endocytosis, phagocytosis or autophagy. In addition to more than 60 hydrolases residing in the lysosomes, there are also ion channels and transporters that mediate the flux or transport of H(+), Ca(2+), Na(+), K(+), and Cl(-)
Xiong, Jian, Zhu, Michael X.
openaire   +2 more sources

Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD

open access: yesCell Reports, 2020
Summary: Amyotrophic lateral sclerosis (ALS) manifests pathological changes in motor neurons and various other cell types. Compared to motor neurons, the contribution of the other cell types to the ALS phenotypes is understudied. G4C2 repeat expansion in
Shuangxi Li   +9 more
doaj   +1 more source

Neurodegeneration Upon Dysfunction of Endosomal/Lysosomal CLC Chloride Transporters

open access: yesFrontiers in Cell and Developmental Biology, 2021
The regulation of luminal ion concentrations is critical for the function of, and transport between intracellular organelles. The importance of the acidic pH in the compartments of the endosomal-lysosomal pathway has been well-known for decades.
Shroddha Bose   +4 more
doaj   +1 more source

Calcium homeostasis modulator (CALHM) ion channels [PDF]

open access: yesPflügers Archiv - European Journal of Physiology, 2015
Calcium homeostasis modulator 1 (CALHM1), formerly known as FAM26C, was recently identified as a physiologically important plasma membrane ion channel. CALHM1 and its Caenorhabditis elegans homolog, CLHM-1, are regulated by membrane voltage and extracellular Ca(2+) concentration ([Ca(2+)]o).
Zhongming, Ma   +3 more
openaire   +2 more sources

Transcriptional regulation of salinity stress: role and spatio-temporal expressions of ion-transporter gene promoters

open access: yesBiologia Plantarum, 2018
Ion transporters play an important role in ion homeostasis and control ion flow from its intrusion to exclusion in the entire plant system. Abiotic stress tolerance in plants depends immensely on the activity of these transporters.
P. K. Agarwal, A. Dave, P. Agarwal
doaj   +1 more source

Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management

open access: yesMolecules, 2022
Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis impeding ...
Pratibha Pandey   +5 more
doaj   +1 more source

Ion activities and potassium uptake mechanisms of glial cells in guinea-pig olfactory cortex slices. [PDF]

open access: yes, 1987
1. Double-barrelled ion-sensitive micro-electrodes were used to measure changes in the intracellular activities of K+, Na+ and Cl- (aiK, aiNa, aiCl) in glial cells of slices from guinea-pig olfactory cortex during repetitive stimulation of the lateral ...
Ballanyi, Klaus   +2 more
core  

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