Results 41 to 50 of about 382,707 (149)

Neurodegeneration Upon Dysfunction of Endosomal/Lysosomal CLC Chloride Transporters

Frontiers in Cell and Developmental Biology, 2021
The regulation of luminal ion concentrations is critical for the function of, and transport between intracellular organelles. The importance of the acidic pH in the compartments of the endosomal-lysosomal pathway has been well-known for decades.
Shroddha Bose, Hailan He, Hailan He, Tobias Stauber, Tobias Stauber   +4 more
doaj   +1 more source

Environmental concentrations of N-nitrosodiethylamine (NDEA) disturb the Ca2 + and K+ homeostasis in the gills and epidermis of mosquitofish (Gambusia affinis)

Ecotoxicology and Environmental Safety
N-nitrosodiethylamine (NDEA), a nitrogenous disinfection by-product, is notorious for its ubiquitous presence in the environment and its carcinogenic properties. However, its impact on ion homeostasis in aquatic organisms remains underexplored.
Xiaoyu Yan, Wenwen Chen, Xiaohong Song, Yun Ma, Haiqin Wang, Tao Yang, Yanpeng Liang, Honghu Zeng   +7 more
doaj   +1 more source

Transcriptional regulation of salinity stress: role and spatio-temporal expressions of ion-transporter gene promoters

Biologia Plantarum, 2018
Ion transporters play an important role in ion homeostasis and control ion flow from its intrusion to exclusion in the entire plant system. Abiotic stress tolerance in plants depends immensely on the activity of these transporters.
P. K. Agarwal, A. Dave, P. Agarwal
doaj   +1 more source

Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management

Molecules, 2022
Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis impeding ...
Pratibha Pandey, Fahad Khan, Huda A. Qari, Tarun Kumar Upadhyay, Abdulhameed F. Alkhateeb, Mohammad Oves   +5 more
doaj   +1 more source

Ion homeostasis in a salt-secreting halophytic grass [PDF]

AoB Plants, 2015
Salinity adversely affects plant growth and development, and disturbs intracellular ion homeostasis, resulting in cellular toxicity. Plants that tolerate salinity, halophytes, do so by manifesting numerous physiological and biochemical processes in coordination to alleviate cellular ionic imbalance.
Sanadhya, Payal, Agarwal, Parinita, Agarwal, Pradeep K.   +2 more
openaire   +2 more sources

Zebrafish as an animal model to study ion homeostasis [PDF]

Pflügers Archiv - European Journal of Physiology, 2013
Zebrafish (Danio rerio) possesses several advantages as an experimental organism, including the applicability of molecular tools, ease of in vivo cellular observation and functional analysis, and rapid embryonic development, making it an emerging model for the study of integrative and regulatory physiology and, in particular, the epithelial transport ...
Hwang, Pung-Pung, Chou, Ming-Yi
openaire   +2 more sources

Exogenous Brassinolide Alleviates Salt Stress in Malus hupehensis Rehd. by Regulating the Transcription of NHX-Type Na+(K+)/H+ Antiporters

Frontiers in Plant Science, 2020
Brassinolide (BL) mediates various physiological processes and improves plant tolerance to abiotic stresses. However, the effects and mechanism of exogenous BL on the salt tolerance of apple seedlings remain unclear.
Qiufang Su, Qiufang Su, Xiaodong Zheng, Xiaodong Zheng, Yike Tian, Yike Tian, Caihong Wang, Caihong Wang   +7 more
doaj   +1 more source

Nano-improved plant salinity tolerance: The importance of K+/Na+ homeostasis and crosstalk between Ca2+ and hormones

Plant Nano Biology
Salinity stress is a major constraint on plant organ morphogenesis, and agricultural production, mostly by disrupting ion homeostasis and plant water status, leading to detrimental K+/Na+ imbalance.
Ibrahim A.A. Mohamed, Mohamed Frahat Foda, Irfan Ullah Khan, Maria Batool, Eman F.A. Awad-Allah, Chenjie Fan, Chengcheng Fu, Jie Wang, Zujun Yin, Honghong Wu   +9 more
doaj   +1 more source

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1

Nature Communications, 2018
Na+-coupled acid-base membrane transport proteins regulate blood pressure, ion homeostasis and acid-base chemistry. Here the authors present the 3.9 Å resolution cryoEM structure of the sodium-bicarbonate cotransporter NBCe1 and characterize its ion ...
Kevin W. Huynh, Jiansen Jiang, Natalia Abuladze, Kirill Tsirulnikov, Liyo Kao, Xuesi Shao, Debra Newman, Rustam Azimov, Alexander Pushkin, Z. Hong Zhou, Ira Kurtz   +10 more
doaj   +1 more source

Ion Homeostasis in Rhythmogenesis: The Interplay Between Neurons and Astroglia [PDF]

Physiology, 2015
Proper function of all excitable cells depends on ion homeostasis. Nowhere is this more critical than in the brain where the extracellular concentration of some ions determines neurons' firing pattern and ability to encode information. Several neuronal functions depend on the ability of neurons to change their firing pattern to a rhythmic bursting ...
Kadala, Aklesso, Verdier, Dorly, Morquette, Philippe, Kolta, Arlette   +3 more
openaire   +2 more sources