Results 51 to 60 of about 540,378 (195)

Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies

Pharmacological Research
The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy ...
Yanjiao Zhang, Kaile Ma, Xinyi Fang, Yuxin Zhang, Runyu Miao, Huifang Guan, Jiaxing Tian   +6 more
doaj   +1 more source

Promising Antifungal Targets Against Candida albicans Based on Ion Homeostasis

Frontiers in Cellular and Infection Microbiology, 2018
In recent decades, invasive fungal infections have been increasing significantly, contributing to high incidences and mortality in immunosuppressed patients. Candida albicans (C.
Yiman Li, Licui Sun, Chunyan Lu, Ying Gong, Min Li, Shujuan Sun   +5 more
doaj   +1 more source

Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management

Molecules, 2022
Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis impeding ...
Pratibha Pandey, Fahad Khan, Huda A. Qari, Tarun Kumar Upadhyay, Abdulhameed F. Alkhateeb, Mohammad Oves   +5 more
doaj   +1 more source

Transcriptional regulation of salinity stress: role and spatio-temporal expressions of ion-transporter gene promoters

Biologia Plantarum, 2018
Ion transporters play an important role in ion homeostasis and control ion flow from its intrusion to exclusion in the entire plant system. Abiotic stress tolerance in plants depends immensely on the activity of these transporters.
P. K. Agarwal, A. Dave, P. Agarwal
doaj   +1 more source

A P-type ATPase importer that discriminates between essential and toxic transition metals [PDF]

, 2009
Transition metals, although being essential cofactors in many physiological processes, are toxic at elevated concentrations. Among the membrane-embedded transport proteins that maintain appropriate intracellular levels of transition metals are ATP-driven
A. T. Lee, Agranoff, Arguello, Arg  ello, Axelsen, Bal, Bull, D. C. Rees, Finney, Francis, Grass, Johnson, Krogh, Legatzki, Lewinson, Melchers, Nies, O. Lewinson, Papp-Wallace, Phung, Rensing, Schafer, Sharma, Thompson, Trenor, Vulpe   +25 more
core   +2 more sources

Ion flux profiles and plant ion homeostasis control under salt stress [PDF]

Plant Signaling & Behavior, 2009
The ability of a plant to maintain an ionic homeostasis is crucial in plant salt tolerance. Direct evidence based on data from the non-invasive measurement of ion fluxes would not only offer new insight about the function of the transporter but also provide a whole plant approach for dissecting salt adaptation mechanisms.
Jian, Sun, Shao-Liang, Chen, Song-Xiang, Dai, Rui-Gang, Wang, Ni-Ya, Li, Xin, Shen, Xiao-Yang, Zhou, Cun-Fu, Lu, Xiao-Jiang, Zheng, Zan-Min, Hu, Zeng-Kai, Zhang, Jin, Song, Yue, Xu   +12 more
openaire   +2 more sources

Environmental concentrations of N-nitrosodiethylamine (NDEA) disturb the Ca2 + and K+ homeostasis in the gills and epidermis of mosquitofish (Gambusia affinis)

Ecotoxicology and Environmental Safety
N-nitrosodiethylamine (NDEA), a nitrogenous disinfection by-product, is notorious for its ubiquitous presence in the environment and its carcinogenic properties. However, its impact on ion homeostasis in aquatic organisms remains underexplored.
Xiaoyu Yan, Wenwen Chen, Xiaohong Song, Yun Ma, Haiqin Wang, Tao Yang, Yanpeng Liang, Honghu Zeng   +7 more
doaj   +1 more source

Cellular mechanisms of potassium homeostasis in the mammalian nervous system [PDF]

, 1987
Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl- (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex.
Ballanyi, Klaus, Grafe, Peter
core   +1 more source

C. elegans fatty acid two-hydroxylase regulates intestinal homeostasis by affecting heptadecenoic acid production [PDF]

, 2018
Background/Aims: The hydroxylation of fatty acids at the C-2 position is the first step of fatty acid α-oxidation and generates sphingolipids containing 2-hydroxy fatty acyl moieties.
Fu, Rong, Huang, Yikai, Li, Yuanbao, Padakanti, Prashanth K., Shi, Xiaoruo, Su, Xiong, Tu, Zhude, Wang, Chunxia, Zhang, Huimin, Zheng, Hanxi, Zhu, Yi   +10 more
core   +3 more sources

Exomer Is Part of a Hub Where Polarized Secretion and Ionic Stress Connect

Frontiers in Microbiology, 2021
Plasma membrane and membranous organelles contribute to the physiology of the Eukaryotic cell by participating in vesicle trafficking and the maintenance of ion homeostasis.
Sandra Moro, Sandra Moro, Esteban Moscoso-Romero, Esteban Moscoso-Romero, Abhishek Poddar, Jose M. Mulet, Pilar Perez, Qian Chen, M.-Henar Valdivieso, M.-Henar Valdivieso   +9 more
doaj   +1 more source