Structural and Quantitative Analysis of Polyfluoroalkyl Substances (PFASs) and Para-Phenylenediamines (PPDs) by Direct Analysis in Real Time Ion Mobility Mass Spectrometry (DART-IM-MS) [PDF]
MoleculesPolyfluoroalkyl substances (PFASs) and para-phenylenediamines (PPDs) are emerging classes of anthropogenic contaminants that are environmentally persistent (most often found in ground and surface water sources), bioaccumulative, and harmful to human ...
Calum Bochenek +3 more
doaj +3 more sources
Targeted glucocorticoid analysis using ion mobility-mass spectrometry (IM-MS). [PDF]
J Mass Spectrom Adv Clin Lab, 2022 Ion mobility-mass spectrometry (IM-MS) is an emerging technique in the -omics fields that has broad potential applicability to the clinical lab. As a rapid, gas-phase structure-based separation technique, IM-MS offers promise in isomer separations and can be easily combined with existing LC-MS methods (i.e., LC-IM-MS).
Neal SP +3 more
europepmc +6 more sources
Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section. [PDF]
Chem Rev, 2023 The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-MS) techniques has provided substantial insights into the field of structural biology over the past two decades. An IM-MS workflow applied to a given target analyte provides mass, charge, and conformation, and all three of these can be used to discern structural ...
Christofi E, Barran P.
europepmc +5 more sources
Ion Mobility–Mass Spectrometry Imaging: Advances in Biomedical Research [PDF]
BioTechMass spectrometry imaging (MSI) visualizes the spatial distribution of biomolecules in tissues, whereas ion mobility–mass spectrometry (IM-MS) separates ions through the collision cross-section (CCS) with an inert gas, providing the structural ...
Mengya Liu +10 more
doaj +2 more sources
Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility-Mass Spectrometry (IM-MS). [PDF]
Methods Mol Biol, 2019 This chapter provides a broad overview of ion mobility-mass spectrometry (IM-MS) and its applications in separation science, with a focus on pharmaceutical applications. A general overview of fundamental ion mobility (IM) theory is provided with descriptions of several contemporary instrument platforms which are available commercially (i.e., drift tube
Phillips ST +3 more
europepmc +3 more sources
Effects of Different Adduct Ions, Ionization Temperatures, and Solvents on the Ion Mobility of Glycans [PDF]
MoleculesThe structural analysis of glycans remains a major challenge due to their high isomeric complexity and conformational flexibility arising from diverse glycosidic linkages and dynamic three-dimensional structures.
Hao Feng, Takumi Yamaguchi
doaj +2 more sources
Rapid Enantiomeric Ratio Determination of Multiple Amino Acids Using Ion Mobility-Mass Spectrometry [PDF]
MoleculesChiral analysis is becoming increasingly important across various scientific fields, including chemistry, pharmaceuticals, biosciences, and more recently, metabolomics.
Wenqing Xu +2 more
doaj +2 more sources
Analytical Strategies for Natural Mono- and Disaccharide Isomer Differentiation: Techniques and Applications [PDF]
Drug Design, Development and TherapyRong Yang,1,2,* Ziwei Deng,3,* Jing Liu,1,2 Zhihua Shi,3 Yueping Jiang1– 3 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People’s Republic of China; 2National Clinical Research Center for ...
Yang R, Deng Z, Liu J, Shi Z, Jiang Y
doaj +2 more sources
Ion Mobility-Mass Spectrometry and its Applications in Protein Glycosylation Research [PDF]
Zhipu Xuebao, 2022 Glycosylation is one of the most important post-translational modifications (PTM), mediating physiological processes like cell adhesion, cell proliferation, cell signaling, and immune responses.
FU Bin1, LIANG Yu-ying1, LU Hao-jie1,2
doaj +1 more source
Recent Progress in Protein Stereochemical Modifications Revealed by Ion Mobility-Mass Spectrometry [PDF]
Zhipu Xuebao, 2022 Protein stereochemical modification (SCM) is a unique type of low-abundance post-translational modification associated with many human diseases. Because it does not change the molecular weight of proteins, traditional proteomics methods are generally not
XU Xia1 +3 more
doaj +1 more source