Results 71 to 80 of about 2,450,645 (310)

External Second Gate, Fourier Transform Ion Mobility Spectrometry: Parametric Optimization for Detection of Weapons of Mass Destruction

Sensors, 2004
: Ion mobility spectrometry (IMS) is recognized as one of the most sensitive and robust techniques for the detection of narcotics, explosives and chemical warfare agents. IMS is widely used in forensic, military and security applications.
Edward E. Tarver
doaj   +1 more source

Cyclic ion mobility for hydrogen/deuterium exchange-mass spectrometry applications [PDF]

, 2023
Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful tool to probe protein dynamics. As a bottom-up technique, HDX-MS provides information at peptide-level resolution, allowing structural localisation of dynamic changes ...
Satomi, Inaba-Inoue, Malcolm, Anderson, Keith, Richardson, Kevin, Giles, Michael , Morris, William J., Allen, Konstantinos, Beis, Ian, Collinson, Argyris, Politis, Damon, Griffiths   +9 more
core   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

A multi-dimensional approach combining HPLC, ion mobility and high resolution mass spectrometry for investigating transition metal complexes

Scientific Reports
Organometallic complexes play a central role in catalysis and medicinal chemistry, yet their analytical characterization via mass spectrometry remains challenging due to their reactivity, susceptibility to fragmentation and the resulting overlapping ...
Laura Zellner, Julian Süß, Samuel Vorbach, Uwe Monkowius, Markus Himmelsbach, Stephan Hann, Christian W. Klampfl   +6 more
doaj   +1 more source

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

Nature Communications, 2020
Heparan sulfates (HS) contain functionally relevant structural motifs, but determining their monosaccharide sequence remains challenging. Here, the authors develop an ion mobility mass spectrometry-based method that allows unambiguous characterization of
Rebecca L. Miller, Scott E. Guimond, Ralf Schwörer, Olga V. Zubkova, Peter C. Tyler, Yongmei Xu, Jian Liu, Pradeep Chopra, Geert-Jan Boons, Márkó Grabarics, Christian Manz, Johanna Hofmann, Niclas G. Karlsson, Jeremy E. Turnbull, Weston B. Struwe, Kevin Pagel   +15 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Ion Mobility Spectrometry as a Part of a System for Rapid Detection of Toxic Chemicals

Safety & Fire Technology, 2019
Aim: The aim of this paper is to present ion mobility spectrometry as a method for the local detection of chemical contaminants. Introduction: According to the doctrine currently in force in the Military Forces of the Republic of Poland, contamination
Władysław Harmata
doaj   +1 more source

Chemical standards in ion mobility spectrometry [PDF]

The Analyst, 2010
In ion mobility spectrometry (IMS), reduced mobility values (K(0)) are used as a qualitative measure of gas phase ions, and are reported in the literature as absolute values. Unfortunately, these values do not always match with those collected in the field.
Roberto, Fernández-Maestre, Charles Steve, Harden, Robert Gordon, Ewing, Christina Lynn, Crawford, Herbert Henderson, Hill   +4 more
openaire   +2 more sources

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Ion Mobility–Mass Spectrometry Imaging: Advances in Biomedical Research

BioTech
Mass spectrometry imaging (MSI) visualizes the spatial distribution of biomolecules in tissues, whereas ion mobility–mass spectrometry (IM-MS) separates ions through the collision cross-section (CCS) with an inert gas, providing the structural ...
Mengya Liu, Chi Zhang, Lili Xu, Md. Muedur Rahman, Shoshiro Hirayama, Shuhei Aramaki, Atsushi Baba, Ryo Omagari, Yutaka Takahashi, Tomoaki Kahyo, Mitsutoshi Setou   +10 more
doaj   +1 more source