Results 101 to 110 of about 20,265 (247)

Imaging mass spectrometry of isotopically-resolved intact proteins on a trapped ion-mobility quadrupole time-of-flight mass spectrometer [PDF]

, 2023
In this work, we demonstrate rapid, high spatial, and high spectral resolution imaging of intact proteins by matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) on a hybrid quadrupole-reflectron time-of-flight (qTOF) mass ...
Jeffrey, Spraggins, Emilio, Rivera, Richard, Caprioli, Dustin, Klein   +3 more
core   +1 more source

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

Mass Spectrometry Reviews, EarlyView.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source

Unraveling the thermal decomposition and chemical ionization of methionine using ion mobility spectrometry and computational chemistry

Scientific Reports
Methionine, an essential amino acid, plays a crucial role in various biological processes and exhibits antioxidant properties, significantly impacting the health and well-being of humans, livestock, poultry, and fisheries.
Mina Amiri, Morteza Vahedpour, Hamed Bahrami, Hamed Douroudgari   +3 more
doaj   +1 more source

Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples

Journal of Pharmaceutical Analysis
The collision cross-sections (CCS) measurement using ion mobility spectrometry (IMS) in combination with mass spectrometry (MS) offers a great opportunity to increase confidence in metabolite identification.
Alongkorn Kurilung, Suphitcha Limjiasahapong, Khwanta Kaewnarin, Pattipong Wisanpitayakorn, Narumol Jariyasopit, Kwanjeera Wanichthanarak, Sitanan Sartyoungkul, Stephen Choong Chee Wong, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara, Yongyut Sirivatanauksorn, Sakda Khoomrung   +11 more
doaj   +1 more source

Combining Laser‐Induced Edition to Collision‐Induced Sequencing of Digital Oligomers in a Single Gas‐Phase Experiment

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale To increase the confidentiality level of molecular tags, binary information can be hidden in sequence‐defined oligomers using isobaric monomers including a photo‐sensitive one, which mass can be modified upon light irradiation. Reading such secured data requires light edition prior to MS/MS sequencing, which was investigated here in ...
Clothilde Comby‐Zerbino, Jean‐François Lutz, Luke MacAleese, Laurence Charles   +3 more
wiley   +1 more source

Deciphering Branched Galactomannan Structures via Multistage Ion Mobility MS and MSn Fragmentation (Multistage IMSn)

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Hemicelluloses are abundant carbohydrate components in plant cell walls. They play a crucial structural role in binding cellulose microfibrils, in addition to other biological functions. Their high structural variability directly influences their biological properties, making it important to establish a structure–function ...
Rania Benazza, Mathieu Fanuel, Hélène Rogniaux, David Ropartz   +3 more
wiley   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source

IMS2 – An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath

Journal of Integrative Bioinformatics, 2007
IMS2 is an Integrated Medical Software system for the analysis of Ion Mobility Spectrometry (IMS) data. It assists medical staff with the following IMS data processing steps: acquisition, visualization, classification, and annotation.
Baumbach Jan, Bunkowski Alexander, Lange Sita, Oberwahrenbrock Timm, Kleinbölting Nils, Rahmann Sven, Baumbach Jörg Ingo   +6 more
doaj   +1 more source

Ion Mobility Spectrometry as a Potential Tool for Flavor Control in Chocolate Manufacture

Foods, 2019
Chocolate has a complex flavor profile composed of more than 600 volatile compounds that mainly arise from the thermo-mechanical treatment during roasting and conching. The aim of this study was to evaluate the applicability of ion mobility spectrometry (
Carolin Schmidt, Doris Jaros, Harald Rohm   +2 more
doaj   +1 more source

Interplay Between Oxidation State, Intervalence Charge Transfer Transitions and Electronic Conductivity in a Series of Ru‐Based Metal–Organic Frameworks

Small, EarlyView.
Ru‐based square‐grid metal–organic frameworks undergo dramatic conductivity enhancements after chemical oxidation. The mixed‐valent states exhibit the highest conductivity values, which correlate with the appearance of intervalence charge transfer bands.
Wang Zhang, Chunyu Luo, Hiroaki Suzuki, Hiroyoshi Ohtsu, Kiyohiro Adachi, Daisuke Hashizume, Bun Chan, Koji Harano, Biplab Manna, Yuki Wada, Masa‐aki Haga, Pavel M. Usov, Masaki Kawano   +12 more
wiley   +1 more source