Results 81 to 90 of about 1,579,972 (289)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

FMI-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli [PDF]

, 2007
The molecular identity and pharmacological properties of mechanically gated ion channels in sensory neurons are poorly understood. We show that FM1-43, a styryl dye used to fluorescently label cell membranes, permeates mechanosensitive ion channels in ...
Wood John N, Wood, John, Drew, LJ, Drew, Liam, Liam J Drew, John N Wood, Wood, JN, Drew Liam J   +7 more
core   +1 more source

Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels [PDF]

, 2020
Trimeric acid-sensing ion channels (ASICs) contribute to neuronal signaling by converting extracellular acidification into excitatory sodium currents. Previous work with homomeric ASIC1a implicates conserved leucine (L7') and consecutive glycine-alanine ...
Pless, Stephan A., Boiteux, Céline, Toby W. Allen, Timothy Lynagh, Stephan A. Pless, Flood, Emelie, Céline Boiteux, Sheikh, Zeshan Pervez, Lynagh, Timothy, Emelie Flood, Allen, Toby W., Zeshan Pervez Sheikh   +11 more
core   +1 more source

Magnesium Selective Ion Channels [PDF]

Biophysical Journal, 2007
The homeostasis of intracellular ion concentrations within physiological limits is one fundamental characteristic of any living organism. Magnesium, an alkaline earth metal, is well known to stabilize macromolecule structure and to participate as an essential cofactor in many enzymatic reactions.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pengaruh Jumlah Mol Kroslinker Pada Selektifitas IIP Berbasis Polieugenol Terhadap Fe(III)

Alchemy, 2018
Sintesis Ionic Imprinted Polymer (IIP) dilakukan dengan variasi penambahan crosslinker PEGDE (Polyethylene glycol diglycidilether) yang kemudian diuji selektivitas IIP terhadap ion logam Fe melalui proses adsorpsi. IIP merupakan metode mencetak ion logam
Muhammad Cholid Djunaidi, Abdul Haris, Pardoyo Pardoyo, Rosdiana K   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Data associated with the publication: Ion channel selectivity through ion modulated changes of selectivity filter pKa values

, 2023
This dataset contains simulations and parameter files associated with the publication "Ion channel selectivity through ion modulated changes of selectivity filter pKa values." Simulation files are in NetCDF format and parameter files are in parm7 format.
Chen, Ada Y., Damjanovic, Ana, Brooks, Bernard R.   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Theory of Ion-Selective Electrodes

Analytical Sciences, 1998
The paper discusses the anomalies of the former interpretation of the working mechanism of ion-selective electrodes. It was thoroughly discussed why the Donnan experiment could not be applied as the theoretical background of glass electrodes. It was assumed according to the Donnan interpretation that the measurable potential is produced by the transfer
openaire   +2 more sources