Results 91 to 100 of about 305,677 (306)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Heavy ion acceleration at CYCLONE (Belgium)

, 1976
CYCLONE is an isochronous cyclotron in operation in Louvain-la-Neuve (Belgium). It is equipped with a P.I.G. hot cathode heavy ion source and accelerates various ions up to energies of 110 MeV Q/sup 2//A with extracted beam intensities reaching 10 mu A ...
Heavy ion sources, Ryckewaert, Guido, Jongen, Yves   +2 more
core  

Ion source of DMS-01 scientific equipment for «AIST no 2» small spacecraft

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2016
The main requirements imposed upon ion sources for on-board time-of-flight mass spectrometers are considered in the paper. An approximate formula to calculate the ionization cross section of an analyte substance is given.
N. D. Semkin, I. V. Piyakov, M. A. Rodina, D. V. Rodin   +3 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Beam driven plasma instabilities in electron beam ion sources

Physical Review Accelerators and Beams
Electron beam ion source (EBIS) is capable of generating highly charged ions by ionizing neutral gas atoms using a high-energy electron beam. The generated ions are confined axially and radially by electric and magnetic fields within the breeding region ...
Chandan Thakur, Sarvesh Kumar, Niketan Jakhar, Sandeep Kashyap, Jyotsna Sharma, Manish K. Kashyap, Hannes Pahl, Fredrik Wenander   +7 more
doaj   +1 more source

A Platform for Laser-Driven Ion Sources Generated with Nanosecond Laser Pulses in the Intensity Range of 10¹³–10¹⁵ W/cm²

Quantum Beam Science
An experimental platform for laser-driven ion (sub-MeV) acceleration and potential applications was commissioned at the HiLASE laser facility. The auxiliary beam of the Bivoj laser system operating at a GW level peak power (~10 J in 5–10 ns) and 1–10 Hz ...
L. Giuffrida, V. Istokskaia, A. Picciotto, V. Kantarelou, M. Barozzi, R. Dell`Anna, M. Divoky, O. Denk, D. Giubertoni, F. Grepl, A. Hadjikyriacou, M. Hanus, J. Krasa, M. Kucharik, T. Levato, P. Navratil, J. Pilar, F. Schillaci, S. Stancek, M. Tosca, M. Tryus, A. Velyhan, A. Lucianetti, T. Mocek, D. Margarone   +24 more
doaj   +1 more source

Ion Heating in Advanced Dielectric Barrier Discharge Ion Sources for Ambient Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom, 2023
Bouza M, Ahmed E, Rocío-Bautista P, Brandt S, Franzke J, Molina-Díaz A, García-Reyes JF, Donald WA.   +7 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source