Results 71 to 80 of about 305,677 (306)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Ion mobility spectrometry: history, characteristics and applications
Revista U.D.C.A Actualidad & Divulgación Científica, 2012 Ion mobility spectrometry (IMS) is an analytical technique that separates ions in the gas phase. Ions are separated at atmospheric pressure under the influence of an electric field, according to their size and shape.
Roberto Fernández Maestre
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
ECR ion sources: the ECREVIS project
, 1983 Two heavy ion sources, using electron cyclotron resonance have been realized in Louvain-la-Neuve. They use a superconducting magnetic structure to confine the plasma. The operational characteristics are explained and present results are shown.
Ryckewaert, Guido +2 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Permanent magnet ECR ion source and LEBT dipole for single-ended heavy ion ToF-ERDA facility
We present the status of the ion source and low energy beam transport prototyping for a single-ended heavy ion time-of-flight elastic recoil detection analysis equipment.
Koivisto, Hannu +6 more
core +1 more source
EFSA Journal, 2010 The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion on the safety of potassium sulphate and sodium sulphate as sources of potassium and sodium, respectively, and on their bioavailabilities from these sources.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Integrated Modeling of the Beam Formation and Extraction in the Linac4 Hydrogen Negative Ion Source
, 2018 In order to make the predictive simulation tools for the extracted beam current and emittance in the Linac4 H− ion source, we have launched the development of the integrated model for the H− ion beam formation and extraction process.
Abe, S. +20 more
core +1 more source