Results 61 to 70 of about 1,383,826 (295)

Simulations of charge-breeding processes in ECRIS

, 2017
Charge-breeding processes in Electron Cyclotron Resonance Ion Sources are numerically simulated by using the target helium plasma parameters obtained with NAM-ECRIS code.
Bogomolov, S., Bondarchenko, A., Efremov, A., Loginov, V., Mironov, V.   +4 more
core   +1 more source

Note: Development of ESS Bilbao's proton ion source: Ion Source Hydrogen Positive

Review of Scientific Instruments, 2014
The Ion Source Hydrogen positive is a 2.7 GHz off-resonance microwave discharge ion source. It uses four coils to generate an axial magnetic field in the plasma chamber around 0.1 T that exceeds the ECR resonance field. A new magnetic system was designed as a combination of the four coils and soft iron in order to increase the reliability of the source.
Miracoli, Rosalba, Feuchtwanger Morales, Jorge, Arredondo López de Gereñu, Iñigo, Belver, Daniel, González, P., Corres Ochoa De Olano, Francisco Javier, Djekic, Slobodan, Echevarria, Pablo, Eguiraun, Mikel, Garmendia, Nagore, Muguira Urtubi, Leire   +10 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Focussing system for an ion source having apertured electrodes Patent [PDF]

, 1967
Apertured electrode focusing system for ion sources with nonuniform plasma ...
Sohl, G., Speiser, R. C.
core   +1 more source

Production of High-Intensity, Highly Charged Ions

, 2014
In the past three decades, the development of nuclear physics facilities for fundamental and applied science purposes has required an increasing current of multicharged ion beams.
Gammino, S.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Ion mobility spectrometry: history, characteristics and applications

Revista U.D.C.A Actualidad & Divulgación Científica, 2012
Ion mobility spectrometry (IMS) is an analytical technique that separates ions in the gas phase. Ions are separated at atmospheric pressure under the influence of an electric field, according to their size and shape.
Roberto Fernández Maestre
doaj   +1 more source

Polarized Negative Ion Source with Multiply Sphericaly Focusing Surface Plasma Ionizer

, 2018
It is proposed one universal H-/D- ion source design combining the most advanced developments in the field of polarized ion sources to provide high-current high-brightness ion beams with >90% polarization and improved lifetime, reliability, and power ...
Dudnikov, A., Dudnikov, V.
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source