Results 111 to 120 of about 96,343 (317)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Conductivity and Electrochemical Studies on Polymer Electrolytes Based on Poly Vinyl (chloride) - Ammonium Triflate-Ionic Liquid for Proton Battery

International Journal of Electrochemical Science, 2013
Solid polymer electrolyte films of poly (vinyl) chloride (PVC) with ammonium trifluoromethane sulfonate (NH4CF3SO3) and ionic liquid, butyltrimethyl ammonium bis (trifluoromethyl sulfonyl) imide (BATS) as plasticizer have been prepared by solution-cast ...
S.K. Deraman, N.S. Mohamed, R.H.Y. Subban   +2 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Effect of Nano-sized Al2O3 Addition on the Sintering Density of Garnet-type Solid Electrolytes

Electrochemistry
Garnet-like oxide lithium ionic conductor Li7La3Zr2O12 (LLZO) exhibits relatively high ionic conductivity and electrochemical stability against lithium metals, attracting much attention as a solid electrolyte for all-solid-state lithium metal batteries ...
Daisuke MORI, Atsushi SUZUKI, Reina ITO, Mana KURODA, Yuki MORI, Yukiya YAMASHITA, Sou TAMINATO, Nobuyuki IMANISHI   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Ionic conductivity in melilite-type silicates [PDF]

, 2014
Aliovalent doping is an effective way to increase conductivity, both electronic and ionic, in ceramic materials. In this study, the transport properties of Sr2MgSi2O7 are investigated and results show that Na-doping in this system introduces ionic ...
Chiodelli G., TEALDI, CRISTINA, FLOR, GIORGIO, Pin S., MALAVASI, LORENZO   +4 more
core   +1 more source

Pair distribution function analysis of sulfide glassy electrolytes for all-solid-state batteries: Understanding the improvement of ionic conductivity under annealing condition

Scientific Reports, 2017
In general, the ionic conductivity of sulfide glasses decreases with their crystallization, although it increases for a few sulphide glasses owing to the crystallization of a highly conductive new phase (e.g., Li7P3S11: 70Li2S-30P2S5).
Shinya Shiotani, Koji Ohara, Hirofumi Tsukasaki, Shigeo Mori, Ryoji Kanno   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Constant-Current Nonequilibrium Molecular Dynamics Approach for Accelerated Computation of Ionic Conductivity Including Ion-Ion Correlation

PRX Energy
Calculation of ionic conductivity including ion-ion correlation effects using equilibrium molecular dynamics (EMD) is computationally demanding, but the correlation is significant in many promising electrolytes such as solid electrolytes. Herein, we have
Ryoma Sasaki, Yoshitaka Tateyama, Debra J. Searles   +2 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source