Results 91 to 100 of about 2,490,039 (260)

Towards advanced Intellectual property management - Events and stages during the development. Evidence from the biotech sector [PDF]

During recent years the management of Intellectual Property (IP) underwent major changes. IP management systems became increasingly complex nowadays actively handling an integrated mix of intellectual assets rather than just administrating patents or ...
Granstrand, Ove, Herstatt, Cornelius, Tietze, Frank   +2 more
core  

Islands of Effective International Adjudication: Constructing an Intellectual Property Rule of Law in the Andean Community [PDF]

, 2009
The Andean Community - a forty-year-old regional integration pact of small developing countries in South America - is widely viewed as a failure. In this Article, we show that the Andean Community has in fact achieved remarkable success within one part ...
Alter, Karen J., Guerzovich, M. Florencia, Helfer, Laurence R.   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The effect of soil on cork quality

Frontiers in Chemistry, 2014
The present work aimed to contribute for a better knowledge regarding soil features as cork quality indicators for stoppers.Cork sampling was made in eight Cork oak stands (montados de sobreiro) located in different Plio-Plistocene sedimentary formations
Miguel Nugent Pestana, Alberto Azevedo Gomes   +1 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

ASPECTE JURIDICE ȘI MEDICALE PRIVIND PROTECȚIA DATELOR DIN BIOBANCA USMF „NICOLAE TESTEMIȚANU”

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale
ucrarea prezintă analiza cadrului normativ și tehnologic aplicabil protecției datelor cu caracter personal în biobanca USMF „Nicolae Testemițanu”. Scopul cercetării a fost evaluarea conformității infrastructurii digitale cu legislația națională și ...
Galina BUTA, Raisa PUIA , Mihail TODIRAȘ, Ghenadie CUROCICHIN   +3 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source

Unlocking Access To Novel Medicines In China-A Review From A Health System Perspective

Risk Management and Healthcare Policy, 2019
Yifan Diao,1 Mingshuang Li,1 Zhiran Huang,1 Jing Sun,1 Yoke Ling Chee,2 Yunali Liu1 1School of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, People’s Republic of China; 2Third World Network ...
Diao Y, Li M, Huang Z, Sun J, Chee YL, Liu Y   +5 more
doaj