Results 71 to 80 of about 2,490,039 (260)
Intellectual Property Management Strategies to Accelerate the Development and Access of Vaccines and Diagnostics: Case Studies on Pandemic Influenza, Malaria and SARS [PDF]
, 2006 Achieving global access to vaccines, diagnostics, and pharmaceuticals remains a challenge. Throughout the developing world, intellectual property (IP) constraints complicate access to critically essential medical technologies and products.
Eiss, Robert +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revista UniVap, 2019 Este artigo tem como objetivo a análise das políticas públicas voltadas ao sistema de coleta e destinação dos resíduos sólidos urbanos na região do Litoral Norte do Estado de São Paulo, composta pelos municípios de Caraguatatuba, Ilhabela, São Sebastião ...
Eliete Gianini de Oliveira +2 more
doaj +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Entramado, 2008 En la selección de Sistemas de Información Contables y Administrativos para la PyME, se debe tener en cuenta tres aspectos básicos, el funcional, el técnico y la metodología de implementación, definidos de la siguiente manera: 1.El aspecto funcional, es ...
Marco Tulio Astudillo Cerón
doaj
A Separation Algorithm for Improved LP-Decoding of Linear Block Codes
, 2008 Maximum Likelihood (ML) decoding is the optimal decoding algorithm for arbitrary linear block codes and can be written as an Integer Programming (IP) problem. Feldman et al.
Hamacher, Horst W. +5 more
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Dwie wizje człowieka - dwie wizje Europy
Chrześcijaństwo-Świat-Polityka, 2017 Artykuł broni tezy, iż współczesne spory o kształt Europy związane są ze sporem dwóch antropologii. Pierwsza z nich, określana tutaj jako antropologia ograniczona, pojmuje człowieka jako stworzenie, a zatem byt w swojej naturze ograniczony i ...
Michał Gierycz, Ks. Piotr Mazurkiewicz
doaj +1 more source