Results 61 to 70 of about 943,098 (265)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Network-based IP flow mobility support in 3GPPs evolved packet core [PDF]
, 2013 Includes bibliographical references.Mobile data traffic in cellular networks has increased tremendously in the last few years. Due to the costs associated with licensed spectrum, Mobile Network Operators (MNOs) are battling to manage these increased ...
John, Charna Tina
core +1 more source
PANCREATITA CRONICĂ - MANAGEMENTUL DIAGNOSTICO - CURATIV MODERN
Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2022 Cercetarea prezintă rezultatele tratamentului chirurgical aplicat la 530 pacienți cu pancreatită cronică (PC) în perioa- da anilor 1990-2022. Intervențiile chirurgicale realizate au fost: pancreatojejunostomie pe ansa Roux(PJA), duodenpan- createctomie ...
Adrian HOTINEANU +2 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Μεταϋπολογισμός βαθμού επικινδυνότητας IP και URL διευθύνσεων
, 2021 Καθώς εισερχόμαστε όλο και πιο βαθιά στην ψηφιακή εποχή, το Διαδίκτυο διαρκώς εξελίσσεται, παρέχοντας νέες καινοτόμες υπηρεσίες. Παρόλο που αυτές οι υπηρεσίες έχουν αναπτυχθεί για να διευκολύνουν τις καθημερινές ανάγκες προωθώντας την χωρίς σύνορα ...
Ριζικός, Ιωάννης
core
What nanotech inventors need to know about trade secrets and the prior user rights defense
Nanotechnology Reviews, 2014 The America Invents Act (AIA) presents new challenges and strategy considerations for nanotechnology inventors and companies that seek to protect their intellectual property in the United States. Among the many notable changes, the AIA expands the “prior
Pham Chinh H., Garsson Ross Spencer
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source