Results 61 to 70 of about 405,317 (235)

POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS E SUA GESTÃO NOS MUNICÍPIOS DO LITORAL NORTE DO ESTADO DE SÃO PAULO

Revista UniVap, 2019
Este artigo tem como objetivo a análise das políticas públicas voltadas ao sistema de coleta e destinação dos resíduos sólidos urbanos na região do Litoral Norte do Estado de São Paulo, composta pelos municípios de Caraguatatuba, Ilhabela, São Sebastião ...
Eliete Gianini de Oliveira, Mário Valério Filho, Rodolfo Moreda Mendes   +2 more
doaj   +1 more source

IP STOCK 2.0 _ IP COINS, IP SHARES & IP INDEXES

This technical specification defines IP Stock 2.0, a breakthrough, self-regulating market infrastructure that materializes hidden Intellectual Property (IP) value ($65–100 trillion) without altering corporate balance sheets or legacy accounting frameworks (IAS 38, IFRS, GAAP).
Michelle, Victor, Michelle, Natalie, Michelle, Emilie, Michelle, Elias   +3 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Consideraciones para la selección de sistemas de información contables y administrativos en la Pyme colombiana

Entramado, 2008
En la selección de Sistemas de Información Contables y Administrativos para la PyME, se debe tener en cuenta tres aspectos básicos, el funcional, el técnico y la metodología de implementación, definidos de la siguiente manera: 1.El aspecto funcional, es ...
Marco Tulio Astudillo Cerón
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Dwie wizje człowieka - dwie wizje Europy

Chrześcijaństwo-Świat-Polityka, 2017
Artykuł broni tezy, iż współczesne spory o kształt Europy związane są ze sporem dwóch antropologii. Pierwsza z nich, określana tutaj jako antropologia ograniczona, pojmuje człowieka jako stworzenie, a zatem byt w swojej naturze ograniczony i ...
Michał Gierycz, Ks. Piotr Mazurkiewicz
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source