Results 31 to 40 of about 403,185 (235)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Impact of Admission Control Methods to the Traffic Management
Advances in Electrical and Electronic Engineering, 2015 The paper deals with Admission control methods (AC) in IMS networks (IP multimedia subsystem) as one of the elements that help ensure QoS (Quality of service). In the paper we are trying to choose the best AC method for selected IMS network node to allow
Filip Chamraz, Ivan Baronak
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The problem with annotation. Human labour and outsourcing between France and Madagascar
Big Data & Society, 2023 Artificial intelligence advancements have reignited job displacement debates that focus on how the use of artificial intelligence affects labour, without considering how the production of this technology influences labour division.
Clément Le Ludec +2 more
doaj +1 more source
Indian Journal of Psychiatry, 2017 Byline: K. Kumar Sir, The efforts to include disabled psychiatrically ill individuals in the ambit of the welfare programs for the disabled in India have a delayed start and a long checkered course. Psychiatrists and other mental health workers had been making ardent appeals and personal efforts in discrete and discontinuous ways, to seek parity of ...
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Voz sobre Protocolo de Internet, VoIP
Prisma Tecnológico, 2016 Voz sobre Protocolo de Internet es un nuevo sistema que permite la transmisión de voz en pequeños paquetes a través de una red IP. Esta tecnología presenta ventajas y desventajas, pero lo más sobresaliente de este sistema es la calidad de la voz que ...
Kristel Vega
doaj
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source