Results 191 to 200 of about 944,819 (280)

Peer facilitators in interprofessional education: a promising response to facilitation challenges. [PDF]

BMC Med Educ
Guinat M, Gasser M, Waller D, Didier A, Santschi V, Greppin-Bécherraz C.   +5 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Stroke metrics, safety, and outcomes of telemedicine-administered thrombolytics for acute ischemic stroke: A meta-analysis. [PDF]

World J Crit Care Med
Loggini A, Schwertman A, Hornik J, Dallow K, Hornik A.   +4 more
europepmc   +1 more source

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

Advanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go, Dahee Lee, Minji Kim, Kiseok Han, Gyuho Choi, ChanHui Song, Sanghyun Ahn, Yerim Lee, Jinyoung Lee, Yingxiao Wang, Jung‐Soo Suh, Hwayoung Yun, Tae‐Jin Kim   +12 more
wiley   +1 more source

Seeds of change: First assessment of an interprofessional training for medical and nursing students through INITIAL ("INnovative InTerprofessIonAl Learning in primary care"): A mixed-method evaluation. [PDF]

GMS J Med Educ
Mauch M, Kauffmann J, Berger M, Mahler C, Röhrig N, Fuhr H, Schalhorn F, Koch R, Fritze O, Schrempf S, Sturm H.   +10 more
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Incidence, clinical features and risk factors of interstitial pneumonia in children with acute lymphoblastic leukemia. [PDF]

Ann Hematol
Li Y, Fan Z, Wang LN, Tang YL, Zhang XL, Tan HZ, Zhang YC, Liang C, Liu XJ, Guo CY, Luo XQ, Huang LB, Ke ZY.   +12 more
europepmc   +1 more source

Ejecta‐Modulated Bubble Dynamics Play a Dominant Role in Stone Retropulsion

Advanced Science, EarlyView.
Stone motion during laser ablation is shown to result primarily from asymmetric cavitation bubble collapse, not from ejecta recoil. This challenges long‐standing assumptions and highlights the dominant role of bubble dynamics in laser–material interactions.
Obed S. Isaac, Arpit Mishra, Georgy N. Sankin, Junqin Chen, Pei Zhong   +4 more
wiley   +1 more source

Comparative Analysis of Suprapatellar and Infrapatellar Nailing in Tibial Fracture: A Randomized Clinical Study. [PDF]

J Orthop Case Rep
Sakale HS, Sakarkar S, Agrawal AC, Gaurav P, Kar BK, Baghel A.   +5 more
europepmc   +1 more source