Results 51 to 60 of about 19,341 (309)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Policy-driven Network Simulation: a Resilience Case Study [PDF]

, 2011
Networks must be resilient to challenges such as malicious attacks or network overload and adapt their operation in an autonomous manner. Network simulations enable the testing of complex network scenarios (which would be difficult to emulate using ...
Smith, Paul, Schaeffer-Filho, Alberto, Mauthe, Andreas   +2 more
core  

Studying the Impact of a UDP DoS Attack on the Parameters of VoIP Voice and Video Streams

Future Internet
This work studies the hypothesis of whether the UDP DoS attack affects voice and video flows in a VoIP network. It is a continuation of a previous work that studied the same hypothesis, but the VoIP server was under different types of TCP DoS attacks ...
Ivan Nedyalkov
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

TCP throughput guarantee in the DiffServ Assured Forwarding service: what about the results ? [PDF]

, 2008
Since the proposition of quality of service(QoS) architectures by the Internet Engineering Task Force(IETF), the interaction between TCP and the QoS services has been intensively studied.
Anelli, Pascal, Lochin, Emmanuel
core   +1 more source

Methodology for Studying the Level of Network Security of an IP PBX Server

Telecom
This paper presents a methodology for studying the level of network security of VoIP platforms. The methodology is designed for VoIP platforms where the voice and video traffic passes through and are processed by the VoIP server itself, rather than being
Ivan Nedyalkov
doaj   +1 more source

Deep learning-driven multi-layer intrusion detection and prevention framework for resilient defense against adaptive evasion techniques in modern networks [PDF]

International Journal of Data and Network Science
Current network security technologies face new threats from determined attackers employing advanced evasion techniques such as IP spoofing, tiny fragment attacks, tunneling, and HTML smuggling. Conventional intrusion detection and prevention systems
Dena Abu Laila, Ibrahim Mohd Obeidat, Mohammed Amin, Amer Alqutaish, Mansour Obeidat, Theyazn H. H. Aldhyani   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dynamic grooming in IP over WDM networks: A study with realistic traffic based on GANCLES simulation package

, 2005
Dynamic grooming capabilities lies at the hearth of many envisaged scenarios for IP over Optical networks, but studies on its performance are still in their infancy. This work addresses two fundamental aspects of the problem.
Salvadori E., R. Zsóka, Lo Cigno
core   +1 more source

Model Aspects of Open Access to Multimedia Broadcast Services in the Evolved Packet System

International Journal of Digital Multimedia Broadcasting, 2016
Multimedia broadcast is the most efficient method to distribute identical content to multiple users in the Evolved Packet System (EPS). EPS enables efficient usage of network resources and provisioning of quality of service for every user.
Ivaylo Atanasov, Evelina Pencheva
doaj   +1 more source