Results 61 to 70 of about 19,341 (309)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Denotation and application mechanism of complicated network shared management information model

Tongxin xuebao, 2008
With IP-based environment of complicated network, in order to solve the network management’s problem of system expansibility, multi-domain management, uniform resource description, the method for modeling and using the shared management information model
GAO Zhi-peng, QIU Xue-song, WANG Zhi-li, LI Wen-jing   +3 more
doaj   +2 more sources

The Use of Kernel Density Estimation With a Bio-Physical Model Provides a Method to Quantify Connectivity Among Salmon Farms: Spatial Planning and Management With Epidemiological Relevance

Frontiers in Veterinary Science, 2018
Connectivity in an aquatic setting is determined by a combination of hydrodynamic circulation and the biology of the organisms driving linkages. These complex processes can be simulated in coupled biological-physical models.
Danielle L. Cantrell, Erin E. Rees, Erin E. Rees, Raphael Vanderstichel, Jon Grant, Ramón Filgueira, Crawford W. Revie   +6 more
doaj   +1 more source

Cancer immune control dynamics: a clinical data driven model of systemic immunity in patients with metastatic melanoma

BMC Bioinformatics, 2021
Background Recent clinical advances in cancer immuno-therapeutics underscore the need for improved understanding of the complex relationship between cancer and the multiple, multi-functional, inter-dependent, cellular and humoral mediators/regulators of ...
Harold P. Frisch, Allan Sprau, Virginia F. McElroy, James D. Turner, Laura R. E. Becher, Wendy K. Nevala, Alexey A. Leontovich, Svetomir N. Markovic   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

SatScope: A Data-Driven Simulator for Low-Earth-Orbit Satellite Internet

Future Internet
The rapid development of low-Earth-orbit (LEO) satellite constellations has not only provided global users with low-latency and unrestricted high-speed data services but also presented researchers with the challenge of understanding dynamic changes in ...
Qichen Wang, Guozheng Yang, Yongyu Liang, Chiyu Chen, Qingsong Zhao, Sugai Chen   +5 more
doaj   +1 more source

Network layer: TCP/IP Model

American International Journal of Sciences and Engineering Research, 2018
Networklayer. The networklayer is in charge of information transmission acrossnetworks. This layer handles the directing of information between PCs. Directing requires some mind boggling and critical strategies for a parcel exchanged system structure.
openaire   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Assessing the Impact of DoS Attacks on the Performance of Asterisk-Based VoIP Platforms

Telecom
In this work, a hypothesis is studied as to whether different DoS attacks affect the parameters of voice and video streams, as well as performance, on three different VoIP platforms.
Ivan Nedyalkov, Georgi Georgiev
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source