Results 191 to 200 of about 75,836 (265)

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

The MIME-seq technique allows to monitor the interaction of small non-coding RNAs with Argonaute proteins and their transfer to other cells. [PDF]

Sci Rep
Perrard J, Guay C, Zanou N, Regazzi R.
europepmc   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Understanding and evaluation of the concept of "palliative psychiatry" among service users with chronic and treatment-resistant depression: a qualitative study of service user perspectives. [PDF]

BMC Psychiatry
Gieselmann A, Potthoff S, Cole R, Otte C, Wingenfeld K.   +4 more
europepmc   +1 more source

3D Engineered Dual‐Redox Zinc‐Iodine Microbatteries for Intrinsically Safe on‐Chip Energy Storage

Advanced Science, EarlyView.
Dual‐redox Zn//I2 microbatteries enable high‐performance on‐chip energy storage by combining Zn2+ plating/stripping with reversible I−/I3− chemistry. Integrated with PANI micro‐cathode and 3D porous Au collectors, the system delivers enhanced capacity, energy, and power, advancing safe, CMOS‐compatible microsystems for next‐generation electronics ...
Nibagani Naresh, Sanat Nalini Paltasingh, Yijia Zhu, Xiaopeng Liu, Yujia Fan, Monojit Mondal, Su Jin Heo, Shuhui Li, Mingqing Wang, Shaoliang Guan, Yanzhuo Li, Georgios Nikiforidis, Shahab Akhavan, Ivan P. Parkin, Saroj Kumar Nayak, Michael De Volder, Buddha Deka Boruah   +16 more
wiley   +1 more source

Cytomegalovirus-Based Viral Vectors Elicit Robust Systemic and Tissue-Resident Immune Response Against SARS-CoV-2 Antigens. [PDF]

Eur J Immunol
Cokarić Brdovčak M, Materljan Franki J, Šustić M, Miklić K, Medved M, Gaćina L, Ružić T, Jonjić S, Brizić I, Krmpotić A.   +9 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Patents, genetic resources, and traditional knowledge: the WIPO treaty and the global access and benefit-sharing regime complex. [PDF]

J Law Biosci
Perron-Welch F.
europepmc   +1 more source

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

Financial impact of non-communicable diseases on households with older adults in india: a mixed methods study. [PDF]

BMC Geriatr
Prince D E A, Kodali PB.
europepmc   +1 more source