Results 191 to 200 of about 2,688,485 (288)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti-Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers. [PDF]

J Infect Dis
Knuutila A, Ivaska L, Barkoff AM, van Gageldonk P, Buisman A, Mertsola J, He Q.   +6 more
europepmc   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Fenofibrate Protects Against Antipsychotic-Induced Hyperglycemia Through Weight Loss and FGF21 Dependent Mechanisms. [PDF]

FASEB J
Akcan M, Jeromson S, Baranowski BJ, Bellucci A, Trang S, Eisner K, Babicki-Moore A, Alfares H, Arbeau M, Medak K, Hahn M, Wright DC.   +11 more
europepmc   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Endoscopic Resection of a Rare Inverted Papilloma Involving the Lacrimal Duct and Sac. [PDF]

Cureus
Ríos de Choudens CS, Bures Rodriguez A, Melero Pardo A, Del Valle F, Portela Arraiza JC.   +4 more
europepmc   +1 more source

Machine Learning–Guided Surface Strain Engineering in Connected Platinum–Nickel Nanoparticle Catalysts for Advanced Oxygen Reduction Performance

Advanced Science, EarlyView.
Machine learning‐guided strain engineering enables highly active, durable, support‐free Pt–Ni nanonetwork catalysts for the oxygen reduction reaction. Analysis of a Pt‐based catalyst dataset identifies surface compressive strain as an effective descriptor associated with enhanced activity and provided practical design guidelines.
Aparna Chitra Sudheer, Gopinathan M. Anilkumar, Hidenori Kuroki, Yuuki Sugawara, Takeo Yamaguchi   +4 more
wiley   +1 more source

Newly identified antimicrobial activity of an 8-hydroxyquinoline-based ionophore against multidrug-resistant Enterococcus faecium and Staphylococcus aureus. [PDF]

J Antimicrob Chemother
Li G, El-Deeb IM, Whyte HG, Blaskovich MAT, Walker MJ, von Itzstein M, De Oliveira DMP.   +6 more
europepmc   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Discovery of CD4+ T cell-recognized B. pertussis antigens that reduce airway colonization. [PDF]

JCI Insight
Shamseldin MM, Hall JM, Lawrence GM, Hernandez GM, Liu Y, Aubrey AR, Verzani EK, Deora R, Lovett-Racke A, Abelin JG, Dubey P.   +10 more
europepmc   +1 more source