Results 201 to 210 of about 75,836 (265)

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

AI-generated Feedback Following Social Robotic Virtual Patient Interactions and Medical Student Performance: Nonrandomized Quasi-Experimental Study. [PDF]

JMIR Med Educ
Borg A, Schiött J, Ivegren W, Gentline C, Huss V, Hugelius AM, Jobs B, Ruiz M, Edelbring S, Georg C, Skantze G, Parodis I.   +11 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Associations Between Blast Exposures and Intestinal Permeability and Neurotrauma Symptoms During Mortar Fire Military Tactical Training Operations. [PDF]

Mil Med
Wang Z, Liu Q, Nemes J, Kranfli A, Sullan M, Hoisington A, Brenner LA, Skotak M, LaValle CR, Ge Y, Carr W, Haghighi F.   +11 more
europepmc   +1 more source

Why every clinician should know about intellectual property: A brief primer within an Indian context. [PDF]

Indian J Anaesth
Babu AV, Dhar M.
europepmc   +1 more source

Traditional, complementary, and integrative medicine in a rapidly digitalizing research environment: ethics and intellectual property considerations. [PDF]

BMC Complement Med Ther
Ng JY.
europepmc   +1 more source

Trained immunity agonists given to neonatal mice fail to protect against leptospiral infection in adulthood and may cause adverse effects. [PDF]

Innate Immun
Fernandez M, Vernel-Pauillac F, Pezier T, Lacroix-Lamandé S, Werts C.   +4 more
europepmc   +1 more source

Physicians' expectations of the use of conversational agents in healthcare: a qualitative study. [PDF]

BMC Health Serv Res
Wutz M, Söling S, Köberlein-Neu J.
europepmc   +1 more source

Differential microplastic storage in main channel and backwater sediments of the Kaskaskia River (Illinois, United States). [PDF]

J Environ Qual
Snow M, Walter S, Louison MJ, Sloan JJ, Baraza T.   +4 more
europepmc   +1 more source