Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls [PDF]
BACKGROUND: Increased cancer risk has been reported in Parkinson's disease (PD) patients carrying the leucine rich repeat kinase 2 (LRRK2) G2019S mutation (LRRK2-PD) in comparison with idiopathic PD (IPD). It is unclear whether the elevated risk would
Aasly, Jan +24 more
core +1 more source
Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger +25 more
core +1 more source
The Nordic countries have a long tradition of research studying the impact of the psychosocial work environment on health (1, 2). Fittingly, the Scandinavian Journal of Work, Environment and Health has been a key place for the presentation and discussion
Reiner Rugulies
doaj +1 more source
JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects. [PDF]
Recently, large scale genome-wide association study (GWAS) meta-analyses have boosted the number of known signals for some traits into the tens and hundreds. Typically, however, variants are only analysed one-at-a-time.
Conti, David V +2 more
core +1 more source
Train Wrecks and Track Attacks: An Analysis of Attempts by Terrorists and Other Extremists to Derail Trains or Disrupt Rail Transportation [PDF]
Attempts to sabotage rails and deliberately derail passenger trains have a long history in conventional and guerrilla warfare as well as during some particularly bitter labor disputes in the past.
Butterworth, Bruce R. +1 more
core +1 more source
ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. [PDF]
Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas.
Alessandro Sette +53 more
core +9 more sources
Back-calculating the incidence of infection of leprosy in a Bayesian framework [PDF]
Background: The number of new leprosy cases reported annually is falling worldwide, but remains relatively high in some populations. Because of the long and variable periods between infection, onset of disease, and diagnosis, the recently detected cases
Crump, Ron E., Medley, Graham
core +3 more sources
The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1 [PDF]
Serotype 1 is one of the most common causes of pneumococcal disease worldwide. Pneumococcal protein vaccines are currently being developed as an alternate intervention strategy to pneumococcal conjugate vaccines.
Adzhubei +48 more
core +6 more sources
Sustainable Strategic Urban Planning: Methodology for Urban Renovation At District Level [PDF]
Sustainable urban renovation is characterized by multiple factors (e.g. technical, socio-economic, environmental and ethical perspectives), different spatial scales and a number of administrative structures that should address the evaluation of ...
Arrizabalaga, Eneko +3 more
core +1 more source
Individual patient data meta-analysis of trials investigating the effectiveness of intra-articular glucocorticoid injections in patients with knee or hip osteoarthritis:an OA Trial Bank protocol for a systematic review [PDF]
BACKGROUND: Based on small to moderate effect sizes for the wide range of symptomatic treatments in osteoarthritis (OA), and on the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of ...
Bierma-Zeinstra, Sita M A +7 more
core +1 more source

