Consequences of Biomarker Analysis on the Cost-Effectiveness of Cetuximab in Combination with FOLFIRI as a First-Line Treatment of Metastatic Colorectal Cancer: Personalised Medicine at Work [PDF]
Background Therapies may be more efficacious when targeting a patient subpopulation with specific attributes, thereby enhancing the cost-effectiveness of treatment.
Harty, G., Jarrett, J., Jofre-Bonet, M.
core +1 more source
Working hours and cardiovascular disease
Working hours, including the number and the arrangement thereof – such as shift work, night work, and quick returns – are classic topics in research on work environment and health.
Reiner Rugulies
doaj +1 more source
Early detection of idiopathic Parkinson's disease based on magnetic resonance imaging [PDF]
The diagnosis of idiopathic Parkinson's disease (IPD) is entirely clinical. The fact that neuronal damage begins 5-10 years before occurrence of sub-clinical signs, underlines the importance of preclinical diagnosis.
Benkortbi, K.
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Calculating the interior permanent-magnet motor [PDF]
This paper describes the calculation of torque in a brushless permanent-magnet line-start AC motor by means of the flux-MMF diagram in combination with the finite-element method.
Cossar, C. +4 more
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Impact of outpatient neuraminidase inhibitor treatment in patients infected with influenza A(H1N1)pdm09 at high risk of hospitalization: an Individual Participant Data (IPD) meta-analysis [PDF]
Background: While evidence exists to support the effectiveness of neuraminidase inhibitors (NAIs) in reducing mortality when given to hospitalized patients with A(H1N1)pdm09 virus infection, the impact of outpatient treatment on hospitalization has not ...
Academy of Medical Sciences WT +27 more
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Explosives and Incendiaries Used in Terrorist Attacks on Public Surface Transportation: A Preliminary Empirical Analysis, MTI Report WP 09-02 [PDF]
This report provides data on terrorist attacks against public surface transportation targets and serious crimes committed against such targets throughout the world.
Butterworth, Bruce R., Jenkins, Brian M.
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Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia [PDF]
Streptococcus pneumoniae serotype 1 is one of the leading causes of invasive pneumococcal disease (IPD) in West Africa, with ST618 being the dominant cause of IPD in The Gambia.
Abdullahi +59 more
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Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update. [PDF]
Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4.
Collet, T.H. +3 more
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The historical development of human resource development in the United Kingdom [PDF]
We construct the historical development of the term “human resource development” (HRD) within the United Kingdom. We argue that HRD has been introduced and employed extensively by academics but not taken up with such enthusiasm by professionals and ...
Sambrook, S., Stewart, Jim
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Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe [PDF]
BACKGROUND: Although overweight and obesity have been studied in relation to individual cardiometabolic diseases, their association with risk of cardiometabolic multimorbidity is poorly understood.
Alfredsson, L +29 more
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