Results 301 to 310 of about 116,955 (355)

Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts. [PDF]

Front Immunol
Alemany-Ribes M, Pérez-Soriano A, Santos A, Severino J, Dangla-Valls A, Gigirey-Suárez M, Cohen D, Ezquerra M, Fernandez-Santiago R, Fernandez M, Martí MJ, Baekelandt V, Peelaerts W, Melki R, Compta Y, Batlle-Morera L.   +15 more
europepmc   +1 more source

Evaluating Thiram‐Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches

Environmental Toxicology, EarlyView.
ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho, Chun‐Wei Tung, B. Linju Yen, Chen‐Yi Weng, Ju‐Hsin Hsu, Ming‐Hsien Tsai, Salim Arrokhman, Pinpin Lin   +7 more
wiley   +1 more source

CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease. [PDF]

Alzheimers Res Ther
Lu W, Kawatani K, Ren Y, Nambara T, Jia L, Jeevaratnam S, Lee E, Martinez PR, Izhar T, Wang N, Raulin AC, Wszolek ZK, Bu G, Kanekiyo T, Li Y.   +14 more
europepmc   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Engineering Mitochondrial Biogenesis in iPSC-CMs: CRISPR-Guided Approaches for Advanced Cardiomyocyte Development. [PDF]

J Cardiovasc Dev Dis
Shahannaz DC, Sugiura T, Ferrell BE, Yoshida T.   +3 more
europepmc   +1 more source

Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support

Laura Cáceres-Palomo, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Juan José Pérez-Moreno, Elba Lopez-Oliva, Tau En Lim, Leah DeFlitch, Chang, Serena H., Kampman, Lucas, M. Ryan Corces, Mathew Blurton-Jones, Inés Moreno‐González, Alberto Pascual, Javier Vitorica, Juan Antonio Garcia-Leon, Antonia Gutiérrez   +15 more
openalex   +1 more source

Novel Progress in Limbal Stem Cell Transplantation

Organ Medicine, EarlyView.
Liqin Huang, Liangbo Chen
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation. [PDF]

Elife
Pavel MA, Chen H, Hill M, Sridhar A, Barney M, DeSantiago J, Baskaran A, Owais A, Sandu S, Darbar FA, Ornelas Loredo A, Al-Azzam B, Chalazan B, Rehman J, Darbar D.   +14 more
europepmc   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source