Results 121 to 130 of about 6,981 (147)

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Phase II Trial of Nivolumab in Advanced Solid Tumors Based on Genomic Profiling: BELIEVE Trial (NCCH1901) Subcohort

Cancer Science, EarlyView.
Off‐label nivolumab treatment guided by CGP results was evaluated in 56 patients with advanced solid tumors. TMB‐High was the predominant biomarker leading to nivolumab treatment. Nivolumab showed limited clinical benefit in 50 patients with measurable disease, with an ORR of 16.0%, DCR of 40.0%, median PFS of 2.7 months, and median OS of 7.2 months ...
Masashi Kanai, Kuniko Sunami, Tatsunori Shimoi, Satoshi Nishiwaki, Ichiro Kinoshita, Tetsuhiro Yoshinami, Chigusa Morizane, Yusuke Sato, Toshio Kubo, Mamoru Ito, Hiroshi Nishihara, Toru Mukohara, Hidekazu Shirota, Ryo Ko, Taro Shibata, Manabu Muto, Noboru Yamamoto   +16 more
wiley   +1 more source

Selective Depletion of Tumor‐Infiltrating CD4+CCR8+ Tregs by AZ084, a Novel CCR8 Antagonist

Cancer Science, EarlyView.
AZ084, a novel CCR8 antagonist, selectively targets tumor‐infiltrating CD4+CCR8+ Tregs, reduces their immunosuppressive function, and decreases IL‐10/TGF‐β production. ABSTRACT Regulatory T cells (Tregs) are key mediators of immunosuppression in ovarian cancer, yet strategies for selectively targeting tumor‐infiltrating Tregs remain limited.
Yepeng Mao, Ziqi Tao, Shuna Liu, Zhijie Liu, Yuelu Zhang, Lingfei Zhou, Lina Yan, Ting Wang, Wenwen Shang, Jianfang Lou, Xi Huang, Xin Fu, Fang Wang   +12 more
wiley   +1 more source

Total body irradiation is associated with increased burden of cerebral microbleeds in haematopoietic stem cell transplant recipients

British Journal of Haematology, EarlyView.
Jure Hederih, Asad Charania, Camelia Vladescu, Ira Lacej, Richard Szydlo, Jiri Pavlu, Renuka Palanicawandar, Jose Ros‐Soto, Andrew Innes, Dragana Milojkovic, Eduardo Olavarria, Jane Apperley, Adam Waldman, Nichola Cooper   +13 more
wiley   +1 more source

Oral Health and Well‐Being: Insights From Personal Narratives of Losing Teeth and Living With Dentures

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives To explore how individuals who have lost or have missing teeth and subsequently received dentures make sense of the factors influencing their oral health and well‐being. Methods Thematic and structural narrative analysis was used to evaluate 19 semi‐structured interview transcripts from a secondary dataset of United Kingdom adults ...
Heba Ramadan Salama, Jennifer Burr, Claire Elcock, Barry John Gibson   +3 more
wiley   +1 more source

Police Officer Perspectives of Section 136 Detention Processes for Children in the North of England

Children &Society, EarlyView.
ABSTRACT Section 136 of the Mental Health Act 1983 (also 2025) enables police officers in England and Wales to detain individuals in public places who appear to be experiencing mental distress and require mental health assessment. Whilst detained adults have received research attention, little is known about how Section 136 is used with children.
Jayne Erlam
wiley   +1 more source

Effect of the National Enhanced Service for weight management on the content of annual review consultations for patients living with obesity and hypertension and/or diabetes

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Guidelines specify that clinicians should support patients living with obesity by referring to weight management programmes (WMPs), but clinicians do so infrequently. To provide additional support to patients living with obesity and weight‐related conditions, the UK government instated the National Enhanced Service (NES) for weight management ...
Stella J. P. Haffner, Sarah Mounsey, Rachna Begh, Anisa Hajizadeh, Alice E. Hobson, Paul Doody, Charlotte Albury, Suzanne Mara, Laura Heath, Kayley McPherson, Susan A. Jebb, Paul Aveyard   +11 more
wiley   +1 more source

Greenhouse gases resulting from grid‐connected electricity demand

Contemporary Economic Policy, EarlyView.
Abstract Many businesses would like to claim their electricity use results in no greenhouse gases. Because electricity cannot be traced from specific generators to purchasers, regulators and users propose an approximation. Clean electricity use would meet three conditions, or “pillars.” It must be generated (1) nearby, (2) during the same hour, and (3)
Karl Dunkle Werner, Arik Levinson
wiley   +1 more source