Results 51 to 60 of about 51,891 (312)

Flexible Unusual Ternary‐Component Graded‐Modulus Dielectric Films with High‐Density Capacitive Energy Storage

open access: yesAdvanced Science, EarlyView.
Hierarchical PP–LSR107–BaTiO3 nanocomposite films are fabricated by one‐step extrusion and stretching for roll‐to‐roll manufacture, combining high energy storage and processing flexibility. LSR107 surrounds BaTiO3‐rich regions, locating amorphous PP, decreasing defects, and introducing deep traps that homogenize the electric field and suppress charge ...
Yi Gao   +14 more
wiley   +1 more source

Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation

open access: yesAngewandte Chemie, EarlyView.
The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu   +12 more
wiley   +2 more sources

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

open access: yesAdvanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang   +17 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

open access: yesAdvanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang   +19 more
wiley   +1 more source

Analysis of the Effect of Rail Connection Failure Using the AHP, FMECA, WRPN Methods (Case Study of the Tanjung Karang Station – Rejosari Station Crossing)

open access: yesPendipa
Sambungan rel merupakan titik kritis pada infrastruktur jalan rel yang memengaruhi kenyamanan dan keselamatan perjalanan kereta api penumpang. Penelitian ini menganalisis pengaruh sambungan rel pada lintas Stasiun Tanjung Karang – Stasiun Rejosari ...
Febriyadi   +5 more
doaj   +1 more source

Periodization and modernity(ies) in international politics through R.B.J. Walker and Jens Bartelson

open access: yesCarta Internacional, 2015
Critical investigations in the field of IR have connected its modes of problematization to a modern discourse on politics. In this paper, we propose to further these interrogations by investigating the role of the under-theorization of ‘periodization’ in
Victor Coutinho Lage   +1 more
doaj   +1 more source

The IRI topside parameters [PDF]

open access: yes, 2004
The IRI electron density topside has been constructed on the basis of the data available about thirty years ago. Recently a large amount of data from old topside sounders have been processed to get electron density profiles.
P. Coïsson, S. M. Radicella
core  

A Novel Approach Based on Acceptor–Donor–Acceptor Type Molecules Enhances the Therapeutic Efficacy and Safety of Photothermal Therapy for Osteosarcoma

open access: yesAdvanced Science, EarlyView.
Jin et al. developed IEICO‐F nanoparticles with enhanced photothermal conversion efficiency via optimized push‐pull effect. Under 808 nm laser, these nanoparticles effectively generated heat to kill osteosarcoma cells and exhibited significant tumor suppression in vivo. Therefore, this novel A‐D‐A type molecule‐based photothermal therapy strategy holds
Zhijian Jin   +9 more
wiley   +1 more source

Proteção do Meio Ambiente no MERCOSUL+2: uma Análise à luz do Direito Ambiental

open access: yesRevista Neiba, 2017
O presente trabalho irá discutir a efetividade da proteção ambiental no âmbito do Mercado Comum do Sul (MERCOSUL), já incluindo na análise a Venezuela (2012) e a Bolívia (2015).
Thauan Santos   +2 more
doaj   +1 more source

Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu   +26 more
wiley   +1 more source

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