Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential [PDF]
Open Biology, 2020 Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation.
Johannes Gregor Matthias Rack +5 more
doaj +1 more source
Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR [PDF]
, 2011 Background Ranaviruses (family Iridoviridae) are important pathogens of lower vertebrates. However, little is known about how they circumvent the immune response of their hosts.
Stefan Rothenburg +2 more
core +2 more sources
Extension of the viral ecology in humans using viral profile hidden Markov models. [PDF]
PLoS ONE, 2018 When human samples are sequenced, many assembled contigs are "unknown", as conventional alignments find no similarity to known sequences. Hidden Markov models (HMM) exploit the positions of specific nucleotides in protein-encoding codons in various ...
Zurab Bzhalava +2 more
doaj +1 more source
The Role of Gut Microbiota in Fish Viral Infection: Mechanisms and Microbiota-Targeted Interventions. [PDF]
Aquac NutrViral diseases represent one of the major threats to the global aquaculture industry. In recent years, the relationship between gut microbiota and viral infections in fish has garnered increasing attention. The gut microbiota contributes critically to fish health and is involved in antiviral defense through immune regulation, secretion of microbial ...
Zhao Q, Shao J, Chen Y, Zhang H.
europepmc +2 more sources
Megalocytivirus Infections in Fish, with Emphasis on Ornamental Species
EDIS, 2013 This document is about megalocytiviruses, a group of fish viruses in the family Iridoviridae, which cause systemic infections in various freshwater and marine fish species1.
Roy Yanong, Thomas B. Waltzek
doaj +1 more source
THIRD INTERNATIONAL SYMPOSIUM ON RANAVIRUSES:: ADVANCING THE UNDERSTANDING OF THE THREAT OF RANAVIRUSES TO NORTH AMERICAN HERPETOFAUNA [PDF]
, 2017 Members of the genus Ranavirus, one of five genera withinthe family Iridoviridae, encompass a group of large, doublestrandedDNA viruses that infect all three classes of ectothermicvertebrates: fish, amphibians, and reptiles.
Chinchar, V. Gregory +4 more
core +2 more sources
A broadly applicable method to characterize large DNA viruses and adenoviruses based on the DNA polymerase gene [PDF]
, 2006 Background Many viral pathogens are poorly characterized, are difficult to culture or reagents are lacking for confirmatory diagnoses. We have developed and tested a robust assay for detecting and characterizing large DNA viruses and adenoviruses.
Larry A Hanson +3 more
core +1 more source
Emerging Ranaviral Infectious Diseases and Amphibian Decline
Diversity, 2010 Infectious diseases caused by ranaviruses (RV, family Iridoviridae) not only affect wild amphibian populations but also agriculture and international animal trade.
Jacques Robert
doaj +1 more source
Viruses, 2016 Ranaviruses (Iridoviridae) are large DNA viruses that are causing emerging infectious diseases at an alarming rate in both wild and captive cold blood vertebrate species all over the world. Although the general biology of these viruses that presents some
Jacques Robert, James K. Jancovich
doaj +1 more source
Inflammation-induced reactivation of the ranavirus Frog Virus 3 in asymptomatic Xenopus laevis. [PDF]
PLoS ONE, 2014 Natural infections of ectothermic vertebrates by ranaviruses (RV, family Iridoviridae) are rapidly increasing, with an alarming expansion of RV tropism and resulting die-offs of numerous animal populations.
Jacques Robert +4 more
doaj +1 more source