Results 121 to 130 of about 750,228 (290)

Embedding patient engagement in the R&D process of a life sciences company through co-creation with a patient expert R&D board: a case study

Research Involvement and Engagement
Patient involvement is crucial in healthcare, a factor increasingly recognised by life sciences companies and research institutes. This article presents a case study on Servier, a life sciences company that founded a patient expert board, ahead of ...
Estelle Jobson, Marta Garcia, Danika Sharek, Laura Risueño, Sylvain Arnould, Aude Lemoine-André, Jan Geissler, Ana Amariutei, Sabrina Grigolo, Begonya Nafria Escalera, Thomas Smith, Oriana Sousa, Linda Stone, Janet West   +13 more
doaj   +1 more source

Optimizing biomass use for carbon storage and land use with the OptiBiU model

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Optimal biomass use in a circular bioeconomy requires a system perspective to guide decision‐making. The Optimizing Biomass Use (OptiBiU) model was developed for this purpose. The model distinguishes among primary biomass production, intermediate products, and biobased products, and incorporates recycling.
Pim M. Post, Heleen Ballemans, Argyris Kanellopoulos, Iris Vural Gürsel, Berien Elbersen, Steven Hoek, Remco Kranendonk, Wolter Elbersen, Sjaak Conijn   +8 more
wiley   +1 more source

A pipeline crisis or a sustainability crisis? Local and national succession planning for headteachers in England

British Educational Research Journal, EarlyView.
Abstract Recruiting and retaining school leaders is a challenge in many systems worldwide. Previous research has identified three distinct ways in which succession planning can be conceptualised and approached: a ‘pipeline’ approach seeks to match supply and demand for the posts that need filling; a ‘pool’ strategy involves proactively identifying and ...
Toby Greany, Pat Thomson, Tom Perry, Mike Collins   +3 more
wiley   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Radial capacity and hemodynamics evaluation in vitro and implantable feasibility validation in vivo of thinner bioresorbable polymer vascular stents

BMEMat, EarlyView.
A series of in vitro experiments, numerical simulations and in vivo experiments were conducted to jointly evaluate the effects of different thicknesses of bioabsorbable polymer vascular stents on their radial capacity, hemodynamics and in vivo outcomes.
Chong Chen, Tao Li, Zhongyou Li, Jingyuan Zhou, Zhuo Zhang, Yan Xiong, Rifang Luo, Yu Chen, Yunbing Wang, Ping Fu   +9 more
wiley   +1 more source

Time-course analysis of cisplatin induced AKI in preclinical models: implications for testing different sources of MSCs

Journal of Translational Medicine
Background Kidneys are at risk from drug-induced toxicity, with a significant proportion of acute kidney injury (AKI) linked to medications, particularly cisplatin.
Abantika Ganguly, Shashank Chetty, Rosita Primavera, Steven Levitte, Shobha Regmi, Benjamin William Dulken, Scott M. Sutherland, Wendy Angeles, Jing Wang, Avnesh S. Thakor   +9 more
doaj   +1 more source

Boric Acid Post‐Modified [Al]ZSM‐5 Zeolites: Properties, Acidity, and Ethanol/Ethene Conversion

Chemistry – A European Journal, EarlyView.
The modification of MFI zeolites with boric acid leads to the formation of framework boron, unstable surface species, and unbound deposits. Relevant BAS for catalysis and access to pores are strongly reduced. The boric acid is removed upon converting C1 or C2 alcohols and ethene. ABSTRACT The effect of boric acid post‐modification on [Al]ZSM‐5 zeolites
Zheng Li, Daniel Dittmann, Dennis Strassheim, Michael Dyballa   +3 more
wiley   +1 more source

PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana

Cytoskeleton, EarlyView.
ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes, Norman R. Groves, Jessica Z. Li, Lily N. Thompson, Brian J. Smith, Aman Y. Husbands, Iris Meier   +6 more
wiley   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source