Results 21 to 30 of about 15,350 (196)

Myeloproliferative Neoplasms with Monocytosis

, 2021
Purpose of Review Myeloproliferative neoplasms (MPN) are a heterogeneous group of hematopoietic stem cell neoplasms comprising of polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) that share driver mutations (JAK2 ...
Erika Morsia, Naseema Gangat
core   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Neuroendocrine Neoplasms of the Gut

, 2020
Neuroendocrine neoplasms of the gut are a heterogeneous group of tumors showing different morphological, clinical, prognostic, and molecular features. Currently, these proliferations are classified as “neuroendocrine neoplasms” (NENs), which include two ...
Rindi, Guido, Silvia Uccella, Uccella, Silvia, Stefano La Rosa, Guido Rindi, La Rosa, Stefano   +5 more
core   +1 more source

A unifying concept of uveal pigment cell distribution and dissemination based on an animal model: Insights into ocular melanogenesis

, 2016
Pigmented cells are derived from neural crest cells, which migrate along the peripheral nerve sheets into their specific final region. During their migration, cells progressively acquire pigment-producing capabilities, maturation, and the shape of ...
Langmann, Gerald, Mayer, Christoph, Hofmann-Wellenhof, Rainer, Grinninger, Petra, Zalaudek, Iris, Schwab, Christoph, Wedrich, Andreas, Richtig, Erika, Schwab, Katharina, Wackernagel, Werner   +9 more
core   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Evolutionary Origin of Ocular Melanoma: Associations With rs12913832 G Allele Frequency and Latitude. [PDF]

Cancer Med
The rs12913832 derived (G) allele frequency (blue‐eye allele) was a markedly stronger predictor of ocular melanoma incidence than geographic latitude, with approximately 92% of the latitude effect mediated through allele frequency. These findings indicate that pigmentation‐related genetic variation contributes substantially to global differences in ...
Witzenhausen H, Helgadottir H, Höiom V, Olofsson Bagge R, Stålhammar G.   +4 more
europepmc   +2 more sources

Second neoplasms after oesophageal cancer

, 2007
The authors considered the incidence of second neoplasms among 1,672 oesophageal cancers diagnosed between 1974 and 2004 in the Cancer Registries of the Swiss Cantons of Vaud and Neuchatel, and followed-up to 2004.
Randimbison, Lalao, La Vecchia, Carlo, Levi, Fabio, Te Van, Cong, Maspoli, Manuela   +4 more
core   +1 more source