Results 61 to 70 of about 7,248 (296)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

open access: yesAdvanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang   +12 more
wiley   +1 more source

Sustaining the Rule of Law in the Irish border region will depend on institutional co-operation [PDF]

open access: yes, 2018
The government's White Paper is an important step towards avoiding a 'hard' border in Ireland. However, sustaining the rule of law in the Irish border region will depend on institutional co-operation, writes Jan van Zyl Smit (Bingham Centre for the Rule ...
van Zyl Smit, Jan
core  

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

open access: yesAdvanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick   +8 more
wiley   +1 more source

Satire and Trauma in Patrick McCabe’s The Butcher Boy

open access: yesStudi Irlandesi, 2017
The Butcher Boy (1992) is the third novel by Northern Irish author Patrick McCabe. It tells the story of 12-year-old Francie Brady and is set in the small town of Clones, in western County Monaghan, Ireland in the early 1960s.
Melania Terrazas
doaj   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

open access: yesAdvanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr   +19 more
wiley   +1 more source

The British-Irish Border in the Context of Brexit

open access: yesPrzegląd Strategiczny, 2020
The subject of the paper is reflections on the consequences of Brexit for the functioning of the border between Ireland and Northern Ireland. The author explains what this border means when the United Kingdom is no longer a member of the European Union, and thus the border may be a barrier to the free movement of people, goods, capital and services. At
openaire   +5 more sources

Abortion in Northern Ireland: From Limbo to Law

open access: yesILCEA
If abortion is now (2024) decriminalized North and South of the Irish border, a certain number of legal and non‑legal obstacles prevent Irish women from accessing services of a free, safe and legal termination of pregnancy.
Nathalie Sebbane
doaj   +1 more source

Seedless One‐Pot Synthesis of Colloidal InAs Quantum Dots Enabling a High‐Accuracy Photoplethysmography Oximeter

open access: yesAdvanced Science, EarlyView.
A real‐time, non‐contact photoplethysmography (PPG) system based on InAs colloidal quantum dots (CQDs) synthesized via a seedless injection synthesis is demonstrated. The measured oxygen saturation shows considerable agreement with commercial PPG devices.
Beom Kwan Kim   +8 more
wiley   +1 more source

Diasporas and ambiguous homelands : a perspective on the Irish border

open access: yes, 2006
Revised version of a paper presented at the workshop on “The Irish border in perspective”, Queen’s University, Belfast, 1 October 2004, as part of the programme Mapping frontiers, plotting pathways: routes to North-South cooperation in a divided ...
Howard, Kevin
core  

A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair

open access: yesAdvanced Science, EarlyView.
A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao   +14 more
wiley   +1 more source

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