Results 61 to 70 of about 1,175,103 (355)

Iron: an underrated factor in aging

Aging, 2021
Iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Iron accumulates with aging, and is associated with many age-related diseases; it also shortens the lifespans of several model organisms. Blocking iron absorption through drugs or natural products extends lifespan.
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) study [PDF]

, 2006
Background: Iron has been implicated in the pathogenesis of various disorders. Mutations in the HFE gene are associated with an increase in serum iron parameters.
Alizadeh, B.Z. (Behrooz), Aulchenko, Y.S. (Yurii), Duijn, C.M. (Cornelia) van, Njajou, O.T. (Omer), Oostra, B.A. (Ben), Pols, H.A.P. (Huib), Swinkels, D.W. (Dorine), Zillikens, M.C. (Carola)   +7 more
core   +7 more sources

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

The Iron Age

, 2003
Made available here with permission from the copyright holder: Cambridge University Press.
openaire   +2 more sources

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

L’archéologie préventive suisse

Archéopages, 2012
Switzerland rarely features in the various overviews of the state of development-led archaeology in Europe or the rest of the world. Though in part due to its small size, it is also owed to the way its archaeology, or rather its archaeologies, is ...
Gilbert Kaenel
doaj   +1 more source

Iron Age in Superconductivity [PDF]

Physics and High Technology, 2013
A new high-temperature superconductor based on Fe was discovered in 2008. Since then, intensive and extensive research has been performed on the subject. In this article, we describe the general features of iron-based superconductors, as well as recent developments in theoretical efforts to understand the microscopic mechanism.
Yunkyu Bang, Yeongkwan Kim, Changyoung Kim   +2 more
openaire   +1 more source

Predictors of anemia in preschool children: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. [PDF]

, 2017
Background: A lack of information on the etiology of anemia has hampered the design and monitoring of anemia-control efforts.Objective: We aimed to evaluate predictors of anemia in preschool children (PSC) (age range: 6-59 mo) by country and infection ...
Aaron, Grant J, Addo, O Yaw, Engle-Stone, Reina, Huang, Jin, Macdonald, Barbara, Namaste, Sorrel Ml, Peerson, Janet M, Rayco-Solon, Pura, Rohner, Fabian, Suchdev, Parminder S, Temple, Victor, Varadhan, Ravi, Williams, Anne M, Wirth, James P   +13 more
core  

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source