Results 21 to 30 of about 29,044 (314)

Hydroxyurea-induced hyperpigmentation with iron deposition [PDF]

Dermatology Online Journal, 2019
Hydroxyurea is a chemotherapeutic agent that is used in the treatment of various hematological diseases including chronic myelogenous leukemia, polycythemia vera, and sickle cell anemia. Hydroxyurea is also used to treat psoriasis. Drug-induced hyperpigmentation is a known cutaneous side effect of hydroxyurea along with xerosis, dermal ulcers, and ...
Lee, Kevin P, Vangipuram, Ramya K, Klimas, Natasha K, Sanyal, Soma, Koshelev, Misha V   +4 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Iron Deposition

Transactions of The Electrochemical Society, 1941
There are very limited applications of iron plating today. On the other hand, electro forming with iron and electrowinning of iron have recently met with renewed interest. Detailed instructions for operating the iron sulfate and the iron chloride baths are presented.
openaire   +1 more source

Synovial Iron Deposition in Rheumatoid Arthritis [PDF]

Arthritis & Rheumatism, 1973
AbstractAn isotope ferrokinetic study has been used to study the rate of iron deposition in 13 rheumatoid knees. Iron accumulation occurred only after incorporation of labelled iron into circulating erythrocytes, suggesting that intermittent intraarticular hemorrhages were the source of the deposits.
R M, Bennett, E D, Williams, S M, Lewis, P J, Holt   +3 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mineralography, paragenesis sequence, and sulfur isotopic composition of Baba-Ali and Galali iron ore deposits from the Sanandaj-Sirjan zone, northwest Iran

Journal of Economic Geology
The northern part of the Sanandaj-Sirjan zone hosts important iron deposits formed during the Mesozoic magmatism. The Baba-Ali and Galali ore deposits occurred on the border of Hamedan, Kermanshah, and Kurdistan provinces.
Majid Shirmohammadi, Ali Asghar Sepahi, Mohammad Maanijou, Ashraf Torkian, Mirmohammad Miri , Mahsa Tahmasebi   +5 more
doaj   +1 more source

Mineralogy and electron microprobe studies of magnetite in the Sarab-3 iron Ore deposit, southwest of the Shahrak mining region (east Takab)

Journal of Economic Geology, 2018
Introduction There is an iron mining complex called Shahrak 60 km east of the Takab town, NW Iran. The exploration in the Shahrak deposit (general name for all iron deposits of the area) started in 1992 by the Foolad Saba Noor Co.
Mohammad Maanijou, Leila Khodaei
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Geological interpretation of aeromagnetic data in the middle and lower reaches of the Yangtze river metallogenic belt, China: implications for iron oxide-apatite (IOA) and skarn iron deposit exploration

Frontiers in Earth Science
IntroductionThe Yangtze River Metallogenic Belt (YMB) hosts extensive Mesozoic iron oxide-apatite (IOA) and skarn iron-copper deposits, with significant high-grade iron ore potential. However, the lack of systematic understanding of mineralization types,
Tengfei Ge, Xue Yang, Zhenyu Fan, Jingzi He, Xiuhe Gao, Xingsu Li, Liang Qiu, Zhengguo Fan, Xuzhao Huang   +8 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source