Results 51 to 60 of about 50,885 (308)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Hemorrhage-adjusted iron requirements, hematinics and hepcidin define hereditary hemorrhagic telangiectasia as a model of hemorrhagic iron deficiency.

PLoS ONE, 2013
BackgroundIron deficiency anemia remains a major global health problem. Higher iron demands provide the potential for a targeted preventative approach before anemia develops.
Helen Finnamore, James Le Couteur, Mary Hickson, Mark Busbridge, Kevin Whelan, Claire L Shovlin   +5 more
doaj   +1 more source

The Estimation Method Comparison of Iron Loss Coefficients through the Iron Loss Calculation

Journal of Electrical Engineering and Technology, 2013
A new calculation method for iron loss coefficients is proposed by using the Steinmetz equation from Epstein data. The hysteresis loss must have linear characteristic according to the frequency. However, the existing iron loss coefficients are defined by formula of frequency. In this case, the hysteresis loss has non-linear characteristics by frequency.
Yong-Tae Kim, Gyu-Won Cho, Gyu-Tak Kim
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Effect of Magnetization on the Production Process of Soft Magnetic Composite Stators of Axial Flux Motors

IEEE Access
Axial flux offer a promising and reliable solution for various applications. The use of soft magnetic composite (SMC) materials allows to resolve some of the challenges associated with these motors.
Emir Poskovic, Fausto Franchini, Elisa Fracchia, Silvio Vaschetto, Luca Ferraris, Alberto Tenconi   +5 more
doaj   +1 more source

A computational technique for iron losses in electrical machines [PDF]

, 2016
This paper aims to compare different methods for the computation of the iron losses. First of all, a brief recall on iron losses models is considered. In particular, Bertotti's formula, a homogenization technique and a vectorized Jiles-Atherton model are
Johan Gyselinck, Gyselinck, Johan, Gyselinek, Johan, Luigi Alberti, Sabariego, R.V., Bottesi, Omar, Ruth V. Sabariego, Sabariego, Ruth V., ALBERTI, LUIGI, Omar Bottesi   +9 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

EFFECT OF GRANULOMETRY AND OXYGEN CONTENT ON SMC MAGNETIC PROPERTIES

Acta Metallurgica Slovaca, 2017
The interest around the adoption of Soft Magnetic Composite materials (SMC) in the realization of electric machines, or parts of electric machines, is continuously increasing. The main reason lies on the opportunity to realize magnetic circuits following
Emir Pošković, Fausto Franchini, Marco Actis Grande, Luca Ferraris, Róbert Bidulský   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source