Results 51 to 60 of about 403,852 (306)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Estimation Method Comparison of Iron Loss Coefficients through the Iron Loss Calculation

open access: yesJournal of Electrical Engineering and Technology, 2013
A new calculation method for iron loss coefficients is proposed by using the Steinmetz equation from Epstein data. The hysteresis loss must have linear characteristic according to the frequency. However, the existing iron loss coefficients are defined by formula of frequency. In this case, the hysteresis loss has non-linear characteristics by frequency.
Yong-Tae Kim, Gyu-Won Cho, Gyu-Tak Kim
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The Effect of Magnetization on the Production Process of Soft Magnetic Composite Stators of Axial Flux Motors

open access: yesIEEE Access
Axial flux offer a promising and reliable solution for various applications. The use of soft magnetic composite (SMC) materials allows to resolve some of the challenges associated with these motors.
Emir Poskovic   +5 more
doaj   +1 more source

EFFECT OF GRANULOMETRY AND OXYGEN CONTENT ON SMC MAGNETIC PROPERTIES

open access: yesActa Metallurgica Slovaca, 2017
The interest around the adoption of Soft Magnetic Composite materials (SMC) in the realization of electric machines, or parts of electric machines, is continuously increasing. The main reason lies on the opportunity to realize magnetic circuits following
Emir Pošković   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Comprehensive Investigation of Winding Eddy and Circulating Current Losses of Stator Iron Coreless PMBLDC Motors

open access: yesEnergies, 2023
A method is proposed to comprehensively study the eddy and circulating current losses of stator winding wound by multiple parallel strands, to further improve the power density of stator iron coreless permanent magnet brushless DC (PMBLDC) motors ...
Liu Yang   +5 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Magnetic Field Characteristics and Stator Core Losses of High-Speed Permanent Magnet Synchronous Motors

open access: yesEnergies, 2020
This study focuses on the core losses in the stator region of high-speed permanent magnet synchronous motors, magnetic field characteristics in the load region, and variations in iron losses caused by changes in these areas.
Dajun Tao   +6 more
doaj   +1 more source

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