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Clinica Chimica Acta, 2005
Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the complex mechanisms of normal and disordered iron homeostasis.
Siah, C., Trinder, D., Olynyk, John
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Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the complex mechanisms of normal and disordered iron homeostasis.
Siah, C., Trinder, D., Olynyk, John
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Iron and Isoferritins in Iron Overload
Clinical Science, 19821. The ferritin content of iron-overloaded tissues was higher than that of normal tissues. There was also an increased iron content of ferritin extracted from these tissues. 2. In the limited number of tissues that we examined haemosiderin deposition appeared to be greater in the iron-overloaded livers than in the iron-overloaded spleens.
Alice K. Jacobs +2 more
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Iron Deficiency, Iron Overload
Annals of Internal Medicine, 1972Excerpt To the editor: In his recent editorial (1) Dr. V. F. Fairbanks reviewed the tests available for iron deficiency.
J. Sorbie, L. S. Valberg
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Iron deficiency and iron overload
Critical Reviews in Oncology/Hematology, 1985An up to date review of our knowledge of human iron metabolism is given including problems of iron balance, internal transport, and intracellular mechanisms. Current knowledge of the iron proteins is summarized and this background is used in discussing the pathophysiology of iron deficiency and overload, together with the internal derangements such as ...
Allan Jacobs, A.V. Hoffbrand
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Acta Clinica Belgica, 2000
African iron overload has been recognised in sub-Saharan Africa for seventy years. The condition is distinct from the well-characterised HLA-linked haemochromatosis described in Caucasians. Increased dietary iron intake predisposes to the condition. Recent evidence suggest that African iron overload may be caused by an interaction between increased ...
Ishmael Kasvosve +3 more
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African iron overload has been recognised in sub-Saharan Africa for seventy years. The condition is distinct from the well-characterised HLA-linked haemochromatosis described in Caucasians. Increased dietary iron intake predisposes to the condition. Recent evidence suggest that African iron overload may be caused by an interaction between increased ...
Ishmael Kasvosve +3 more
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New England Journal of Medicine, 2013
Both hemochromatosis and β-thalassemia are caused by a deficiency of hepcidin, which represses expression of ferroportin at the surface of cells that export iron into the blood. Studies suggest that repressing expression of a hepcidin inhibitor ameliorates disease in mouse models.
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Both hemochromatosis and β-thalassemia are caused by a deficiency of hepcidin, which represses expression of ferroportin at the surface of cells that export iron into the blood. Studies suggest that repressing expression of a hepcidin inhibitor ameliorates disease in mouse models.
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Acta Paediatrica, 1989
Halliday, J. W. (The Liver Group, Department of Medicine, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia). Inherited iron overload.Several inherited forms of iron overload have been described. It is now accepted that HC, usually regarded as a disease of adult life, is an inherited disorder, hence all first degree relatives must ...
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Halliday, J. W. (The Liver Group, Department of Medicine, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia). Inherited iron overload.Several inherited forms of iron overload have been described. It is now accepted that HC, usually regarded as a disease of adult life, is an inherited disorder, hence all first degree relatives must ...
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Seminars in Hematology, 2002
Iron overload is common in rural sub-Saharan African populations that have the custom of drinking a traditional fermented beverage with high iron content. As with both excessive alcohol exposure and HFE hemochromatosis, hepatic portal fibrosis and micronodular cirrhosis are prominent sequelae of African iron overload.
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Iron overload is common in rural sub-Saharan African populations that have the custom of drinking a traditional fermented beverage with high iron content. As with both excessive alcohol exposure and HFE hemochromatosis, hepatic portal fibrosis and micronodular cirrhosis are prominent sequelae of African iron overload.
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Clinical Toxicology, 1971
The human body exerts considerable control over iron absorption. This control is very essential since a small amount of this element is lost in the urine or through the gastrointestinal tract [ 11 . Under normal conditions the regulatory mechanism is adequate to maintain a state of iron balance.
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The human body exerts considerable control over iron absorption. This control is very essential since a small amount of this element is lost in the urine or through the gastrointestinal tract [ 11 . Under normal conditions the regulatory mechanism is adequate to maintain a state of iron balance.
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Clinics in Liver Disease, 2002
Because hepatic siderosis is a frequent finding, there is a risk of making it trite when elaborating the pathology report. Iron is increasingly considered an important cofactor of morbidity. Its finding in hepatic cells must be recognized, indicated, qualified, quantified, and interpreted.
Bruno Turlin, Yves Deugnier
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Because hepatic siderosis is a frequent finding, there is a risk of making it trite when elaborating the pathology report. Iron is increasingly considered an important cofactor of morbidity. Its finding in hepatic cells must be recognized, indicated, qualified, quantified, and interpreted.
Bruno Turlin, Yves Deugnier
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