Results 61 to 70 of about 968,189 (263)

A fructose-intolerant yeast strain to select for sucrose fructosyl-transferase activity [PDF]

, 1993
A selection system for yeast cells expressing mutated invertase (EC 3.2.1.26, SUC2) with altered fructotransferase activity was developed based on the survival of a fructose-intolerant strain in the presence of suitable acceptor substrates and sucrose ...
Doyle, Timothy Charles., Doyle, Timothy C.   +1 more
core   +1 more source

Transport–Reaction–Signal Coupling in Lateral Flow Assays for Next‐Generation Point‐of‐Care Diagnostics

Advanced Science, EarlyView.
Lateral flow assays are evolving into interdisciplinary, system‐level sensing platforms. Recent innovations are deconstructed through coupled phases of mass transfer, reaction, and signal transduction, revealing interdependence across porous materials, interfacial chemistry, nanolabels, readout devices, and data‐enabled analysis.
Yan Pan, Yuewei Li, Chao Mi, Zhengwen Yang, Lana McClements, Steven J. Langford, Jiayan Liao   +6 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Comparison of short-term efficacy of iron sucrose with those of ferric chloride in hemodialysis patients: An open-label study

Journal of Research in Medical Sciences, 2016
Background: It is intriguing and imperative that the comparison of the iron preparations in hemodialysis (HD) patients. This study aimed to observe the short-term efficacy of parenteral iron sucrose and ferric chloride in HD patients .
Po-Jen Hsiao, Jenq-Shyong Chan, Kun-Lin Wu, Wen-Fang Chiang, Jing-Shu Huang, Chia-Chao Wu, Pauling Chu, Jin-Shuen Chen   +7 more
doaj   +1 more source

Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects [PDF]

, 2006
Intravenous iron is commonly used in conjunction with erythropoietic agents to treat anemia in patients with chronic kidney disease. Iron has been proposed to promote oxidative stress and endothelial dysfunction in vascular tissues.
Katz, S.D., Zhang, Q., Zheng, H., Huang, X.   +3 more
core   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Intravenous Iron Sucrose Therapy in Anemia with Pregnancy [PDF]

, 2020
Anemia of pregnancy is most common medical disorder in the developing country, affecting 2 billion population worldwide. In India prevalence is 49.7% of pregnancy contributing to 80% of maternal mortality.
Qaddori, Mahassin Qassim
core   +1 more source

Effect of Ferric Carboxymaltose Versus Low-Dose Intravenous Iron Therapy and Iron Sucrose on the Total Cost of Care in Patients with Iron Deficiency Anemia: A US Claims Database Analysis

Drugs - Real World Outcomes
Background and Objective Iron deficiency is the most common cause of anemia. We compared the effect of ferric carboxymaltose (FCM), low-dose intravenous (IV) iron (LDI), and iron sucrose on total cost of care in patients with iron-deficiency anemia (IDA)
Winghan Jacqueline Kwong, Kevin Wang, Peng Wang, Ralph Boccia   +3 more
doaj   +1 more source

Administration of Intravenous Iron Formulations Induces Complement Activation in-vivo

Frontiers in Immunology, 2019
Background: Intravenous (IV) iron is widely used to treat anemia in chronic kidney disease patients. Previously, iron formulations were shown to induce immune activation in-vitro. The current study aimed to investigate the effect of IV iron on complement
Bernardo Faria, Bernardo Faria, Bernardo Faria, Mariana Gaya da Costa, Felix Poppelaars, Casper F. M. Franssen, Manuel Pestana, Stefan P. Berger, Mohamed R. Daha, Mohamed R. Daha, Carlo A. J. M. Gaillard, Marc A. Seelen   +11 more
doaj   +1 more source