Divalent metal transporter 1 (DMT1) in the brain: Implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology [PDF]
Frontiers in Molecular Neuroscience, 2015 Iron is required in a variety of essential processes in the body. In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells.
Torben eMoos
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Residual erythropoiesis protects against myocardial hemosiderosis in transfusion-dependent thalassemia by lowering labile plasma iron via transient generation of apotransferrin [PDF]
Haematologica, 2017 Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis.
Maciej W. Garbowski +4 more
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Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine. [PDF]
PLoS Pathogens, 2015 Dialysis patients with chronic renal failure receiving deferoxamine for treating iron overload are uniquely predisposed for mucormycosis, which is most often caused by Rhizopus oryzae.
Mingfu Liu +8 more
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Akkermansia muciniphila MucT harnesses dietary polyphenols as xenosiderophores for enhanced iron uptake [PDF]
Nature CommunicationsDietary proanthocyanidins (PACs) are polyphenols that promote a healthy gut microbiome. PACs are notable for their rich catechol moieties with high affinity for iron, enabling them to interfere with pathogens’ iron uptake.
Maria-Carolina Rodríguez-Daza +4 more
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Study in the iron uptake mechanism of Pasteurella multocida [PDF]
Veterinary ResearchPasteurella multocida infects a wide range of animals, causing hemorrhagic septicemia or infectious pneumonia. Iron is an essential nutrient for growth, colonization, and proliferation of P.
Xiangxiang Shen +5 more
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Anticancer activity of the iron facilitator LS081 [PDF]
Journal of Experimental & Clinical Cancer Research, 2011 Background Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer cell growth.
Glass Jonathan +3 more
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Type VII secretion system deploys an active iron uptake pathway to enhance bacterial fitness and counteract host nutritional immunity [PDF]
mBioType VII secretion systems (T7SS) are increasingly recognized as pivotal for bacterial adaptation across both environmental and host-associated niches in Gram-positive bacteria.
Chunhui Luo +11 more
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Structural determination of mugineic acid, an iron(III)-chelating substance secreted from graminaceous plants for efficient iron uptake [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesIron is an essential element for organisms, but its solubility in soil is often extremely low. Previously, plants were considered to take up iron only after its reduction to ferrous ions.
Takanori KOBAYASHI, Naoko K.NISHIZAWA
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Hepcidin induces intestinal calcium uptake while suppressing iron uptake in Caco-2 cells.
PLoS ONE, 2021 Abnormal calcium absorption and iron overload from iron hyperabsorption can contribute to osteoporosis as found in several diseases, including hemochromatosis and thalassemia.
Supathra Phoaubon +3 more
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Frontiers in Microbiology, 2022 The roles of TonB mediated Fe3+ (ferric iron) uptake via enterobactin (involving biosynthesis genes entABCDEF) and Fe2+ (ferrous iron) uptake through the FeoABC transporter are poorly defined in the context of chicken-Salmonella interactions. Both uptake
Dinesh H. Wellawa +9 more
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