Results 61 to 70 of about 388,475 (351)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Deletion of the c2515 and c2516 Genes Affects Iron Uptake and Virulence of APEC O1 Strain E516

Frontiers in Veterinary Science, 2021
Avian pathogenic Escherichia coli (APEC), widely spread among poultry, is well-known to cause colibacillosis in chickens, which results in significant losses in poultry industry.
Qingqing Gao, Xi Li, Senyan Su, Lei Yang, Song Gao   +4 more
doaj   +1 more source

Transferrin receptor expression and the regulation of placental iron uptake [PDF]

, 1991
Placental transferrin receptors, located at the apical side of syncytiotrophoblast, mediate placental iron uptake. Regulation of transferrin receptors on the fetal-maternal exchange area could be a major determinant in the regulation of trans-placental ...
Baert, M.R.M. (Miranda), Bierings, M. (Marc), Dijk, J.P. (Johannes) van, Eijk, H.G. (Henk) van   +3 more
core   +1 more source

Iron Uptake inUstilago maydis: Tracking the Iron Path [PDF]

Journal of Bacteriology, 1998
ABSTRACTIn this study, we monitored and compared the uptake of iron in the fungusUstilago maydisby using biomimetic siderophore analogs of ferrichrome, the fungal native siderophore, and ferrioxamine B (FOB), a xenosiderophore. Ferrichrome-iron was taken up at a higher rate than FOB-iron.
Ardon, O., Nudelman, R., Caris, Catherine, Libman, J., Shanzer, A., Chen, Y., Hadar, Y.   +6 more
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Citrus flavanones enhance carotenoid uptake by human intestinal Caco-2 cells [PDF]

, 2009
The health benefit of a diet rich in fruits and vegetables could be attributed to the complex mixture of phytochemicals. It is now widely believed that the actions of the antioxidant microconstituents is a result of additive and/or synergistic effects of
Amiot, Marie Josèphe, Caporiccio, Bertrand, Dhuique-Mayer, Claudie, During, Alexandrine, Tourniaire, Franck   +4 more
core  

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Magez, Stefan, Stijlemans, Benoit   +2 more
core   +2 more sources

Structural biology of bacterial iron uptake

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008
To fulfill their nutritional requirement for iron, bacteria utilize various iron sources which include the host proteins transferrin and lactoferrin, heme, and low molecular weight iron chelators termed siderophores. The iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane ...
Krewulak, Karla D., Vogel, Hans J.
openaire   +2 more sources

New Perspectives on Iron Uptake in Eukaryotes [PDF]

Frontiers in Molecular Biosciences, 2018
All eukaryotic organisms require iron to function. Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron (NTBI).
Sherman HG, Jovanovic C, Stolnik S, Baronian K, Downard AJ, Rawson FJ   +5 more
openaire   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source