Results 171 to 180 of about 34,731 (238)

The chaperonin TRiC component Cct3 is required for axonal transport, myelination, and neuromuscular junction refinement. [PDF]

Cell Death Dis
Zhang X, Zajt KK, Palaz T, Wang L, Groß M, Kraft F, Weis J, Bremer J.   +7 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Primary Hepatic Hemangiosarcoma With Hemoperitoneum in a Dog: Clinical Course and Therapeutic Outcome. [PDF]

Case Rep Vet Med
Lee MY, Moon JH, Mok J, Lim D, Kim JY, Jung SY, Jeong E, Jang H, Jung DI.   +8 more
europepmc   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Large Language Modeling-Enabled Analysis of Atrial Fibrillation on Social Media. [PDF]

J Am Heart Assoc
Parsa S, Somani S, Rogers AJ, Hernandez-Boussard T, Jain SS, Rodriguez F.   +5 more
europepmc   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study.

JMIR Res Protoc
Kuhn-Keller JA, Eiling I, Hirschler L, Václavů L, Witjes-Ané MN, Wijngaarden M, Nagtegaal M, Ercan E, Rius Ottenheim N, van der Elst M, Sohl E, van Buchem MA, Mooijaart S, van Osch MJ, de Bresser J.   +14 more
europepmc   +1 more source

Case Report: Urachal inflammatory myofibroblastic tumor with bladder invasion. [PDF]

Front Oncol
Liu X, Bai D.
europepmc   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Disease susceptibility and biological vulnerability of black vultures to fatal clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) virus infection. [PDF]

Sci Rep
Nemeth NM, Andreasen VA, Weyna AAW, Sargent R, Cunningham M, Kunkel MR, Oesterle PT, Goodwin CC, Teo XH, Hardman R, Stallknecht DE, Ruder MG, Poulson RL.   +12 more
europepmc   +1 more source